Diagnostic performance of tear function tests in Sjogren's syndrome patients
| Autor: | M Frigato, Mauro Cellini, Piera Versura, Nazzarena Malavolta, R. Mulè, Emilio C. Campos |
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| Přispěvatelé: | VERSURA P., FRIGATO M., CELLINI M., MULE R., MALAVOLTA N., CAMPOS E.C. |
| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Pathology CORNEAL ESTESIOMETRY Eye disease Signs and symptoms Diagnostic Techniques Ophthalmological Sensitivity and Specificity Autoimmune Diseases Cornea Diagnosis Differential Lissamine Green Dyes Conjunctival cytology Surveys and Questionnaires Sicca syndrome Ophthalmology TEAR CLEARANCE medicine Humans SJOGREN'S SYNDROME Schirmer test Coloring Agents business.industry Area under the curve Reproducibility of Results Middle Aged LISSAMINE GREEN medicine.disease eye diseases ROC Curve Touch EVIDENCE BASED MEDICINE Tears Dry Eye Syndromes Female Sjogren s business Conjunctiva |
| Zdroj: | Eye. 21:229-237 |
| ISSN: | 1476-5454 0950-222X |
| DOI: | 10.1038/sj.eye.6702204 |
| Popis: | ObjectiveTo evaluate the diagnostic performance of the tests included in primary Sjogren's syndrome (SS-I) diagnostic criteria (Schirmer I, break-up time, vital dye staining) and to compare them with other examinations related to the ocular surface status.MethodsClinical and cytological data were collected from 177 patients (62 SS-1, 56 non-SS autoimmune diseases, 59 Sicca syndrome). Tear tests included: a validated questionnaire on symptoms, Schirmer I, Jones test, Ferning test, BUT, corneal aesthesiometry, tear clearance test, lissamine green staining, impression conjunctival cytology. Data were statistically evaluated and sensitivity, specificity, likelihood ratio (LR+), receiver-operating characteristics (ROC) curves were calculated for each test.ResultsData showed a poor diagnostic performance of Schirmer test I (sensitivity 0.42; specificity 0.76; LR+1.75) and BUT (sensitivity 0.92; specificity 0.17; LR+1.11) (area under the curve in ROC analysis 0.70). Lissamine green staining exhibited the best performance (sensitivity 0.63; specificity 0.89; LR+5.72) but the result could be distorted by an incorporation bias.ConclusionsOur data suggest to implement the items for ocular signs and symptoms contained in many SS-I diagnostic criteria with the use of a validated questionnaire, performance of Jones test, corneal aesthesiometry measurement, and tear clearance rate evaluation. |
| Databáze: | OpenAIRE |
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