Radiotherapy combined with simultaneous chemotherapy with mitomycin-C and 5-fluorouracil for inoperable head and neck cancer
| Autor: | C.F. Hess, Olivier Pradier, K. Eberlein, M C Jackel, E. Weiss |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Larynx
Adult Male medicine.medical_specialty Nausea medicine.medical_treatment Mitomycin Radiation Dosage 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Antineoplastic Combined Chemotherapy Protocols Medicine Humans Radiology Nuclear Medicine and imaging Infusions Intravenous Aged Chemotherapy business.industry Mitomycin C Head and neck cancer General Medicine Middle Aged medicine.disease Combined Modality Therapy 3. Good health Surgery Radiation therapy medicine.anatomical_structure Treatment Outcome Fluorouracil Head and Neck Neoplasms 030220 oncology & carcinogenesis Female medicine.symptom business Tomography X-Ray Computed Chemoradiotherapy medicine.drug Follow-Up Studies |
| Zdroj: | The British journal of radiology. 74(880) |
| ISSN: | 0007-1285 |
| Popis: | The feasibility and effectiveness of a combined chemoradiotherapy treatment modality for locally advanced head and neck cancer was tested in a phase II trial. From March 1995 to June 1998, 35 patients with advanced squamous cell carcinoma of the head and neck were treated with a continuous intravenous infusion of 5-fluorouracil (600 mg m-2 24 h-1 for Days 1 to 5 (120 h)) and mitomycin-C (10 mg m-2 intravenously) on Day 5 during the first week of radiotherapy and on Day 36. 31 patients had stage IV disease; 4 patients had stage III; and 1 patient had stage II. Patient ages ranged from 42-69 years (median 56.7 years). The tumours involved were as follows: oral cavity (n = 11); oropharynx (n = 14); hypopharynx/larynx (n = 10). Radiotherapy was delivered to a total dose of 70 Gy with conventional fractionation (2 Gy per fraction, five times a week). Chemotherapy was well tolerated and all patients received the intended dose. Mild nausea occurred in five patients. After a mean follow-up of 21 months (range 10-44 months), 8 (23%) patients remain alive. A complete response was seen in 28 (80%) patients. When a recurrence appeared, it was within the first year after treatment. 1- and 2-year overall survival rates were 46% and 23%, respectively. Grade 3 mucositis occurred in 17% of patients. Grade 1-2 thrombopaenia occurred in 3 (9%) patients, grade2 leukopaenia in 4 (11%) patients, and gradeor = 2 anaemia in 3 (9%) patients. We observed a treatment interruption of maximum 1 week for six patients owing to mucositis. Febrile neutropaenia or aplasia were not observed. The concomitant use of 5-fluorouracil, mitomycin-C and radiotherapy in locally advanced head and neck carcinoma is well tolerated in this group of patients. This protocol showed good locoregional response with a very low toxicity profile. |
| Databáze: | OpenAIRE |
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