Dialysate Markers of Peritoneal Tissue during Peritonitis and in Stable Capd
| Autor: | Marja M. Pannekeet, Dick G. Struijk, Désirée Zemel, Raymond T. Krediet, Ger C.M. Koomen |
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| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
business.industry medicine.medical_treatment 030232 urology & nephrology Peritonitis Inflammation General Medicine medicine.disease Gastroenterology Surgery Peritoneal dialysis Mesothelium Peritoneal cavity 03 medical and health sciences medicine.anatomical_structure 0302 clinical medicine Peritoneum Nephrology Internal medicine medicine 030212 general & internal medicine medicine.symptom Dialisis peritoneal business |
| Zdroj: | Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis. 15:217-225 |
| ISSN: | 1718-4304 0896-8608 |
| Popis: | ObjectiveTo investigate whether dialysate concentrations of substances that are locally produced within the peritoneal cavity can be used to study the effects of inflammation on peritoneal tissue.DesignWe followed the appearance rates (AR) of concentrations of cancer antigen (CA) 125, phospholipids (PHL), hyaluronan (HA), and the procollagen peptides PICP (procollagen 1 C-terminal) and PIIINP (procollagen 3 N-terminal) in dialysate during peritonitis (8 consecutive days) and after recovery. Data were compared with the stable situation.SettingCAPD (continuous ambulatory peritoneal dialysis) unit in the Academic Medical Center in Amsterdam.PatientsTwelve CAPD patients with a total of 16 episodes of peritonitis and 10 clinically stable CAPD patients were studied.ResultsAll substances showed temporal increments in dialysate during peritonitis compared to control. No difference was found between the control day of peritonitis and the stable patients. Maximum AR were reached in the acute phase of peritonitis for CA 125, PHL, and HA and on day 4 for both PICP and P111NP. A second increment in CA125 occurred on days 4 to 6. These findings indicate acute damage to the mesothelium (CA 125) and other cells (PHL) by the infection. HA may reflect stromal changes. Subsequently, peritoneal healing (PICP, PIIINP) and remesothelialization (second peak CA125) are likely to occur.ConclusionsDialysate concentrations of these substances can be used as markers for the effects of peritonitis on the peritoneum of CAPD patients in vivo. The similarity between the marker concentrations in the effluent after recovery from peritonitis and those in stable CAPD patients implies that complete peritoneal healing is likely to occur after uncomplicated peritonitis. |
| Databáze: | OpenAIRE |
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