Ghrelin and acyl ghrelin levels are associated with inflammatory and nutritional markers and with cardiac and vascular dysfunction parameters in hemodialysis patients

Autor: Cosmina Ioana Bondor, Crina Rusu, Dan Delean, Remus Orasan, Ioan Mihai Patiu, Alexandra Danu, Simona Racasan, Diana Moldovan, Dacian Tirinescu, Alina Potra, Ina Maria Kacso, Dan Vladutiu, Cristian Budurea
Rok vydání: 2018
Předmět:
Male
Nephrology
medicine.medical_specialty
Vascular smooth muscle
Urology
medicine.medical_treatment
Interleukin-1beta
030232 urology & nephrology
Nutritional Status
Inflammation
Comorbidity
030204 cardiovascular system & hematology
Muscle
Smooth
Vascular
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Predictive Value of Tests
Renal Dialysis
Diabetes mellitus
Internal medicine
Natriuretic Peptide
Brain
medicine
Humans
Correlation of Data
Triglycerides
Aged
Romania
business.industry
Cholesterol
digestive
oral
and skin physiology
Middle Aged
medicine.disease
Ghrelin
Peptide Fragments
Cross-Sectional Studies
Endocrinology
chemistry
Cardiovascular Diseases
Kidney Failure
Chronic
Female
Hemodialysis
medicine.symptom
business
Body mass index
Biomarkers
hormones
hormone substitutes
and hormone antagonists
Zdroj: International Urology and Nephrology. 50:1897-1906
ISSN: 1573-2584
0301-1623
Popis: Exogenous ghrelin is associated with cardiovascular protection in experimental and human studies. Nevertheless ESRD patients have increased ghrelin levels and severe cardiovascular comorbidities. This study aims to elucidate the metabolic factors influencing endogenous ghrelin/acyl ghrelin levels and to analyze the relation between endogenous ghrelin/acyl ghrelin levels and cardiac and vascular function markers in hemodialysis patients. The cross-sectional study was conducted in hemodialysis patients (n = 88); 50 of them were men, mean age 61.1 ± 13.5 years, 17% had diabetes. We assessed nutritional and inflammatory status and analyzed the determinants of ghrelin/acyl ghrelin and their relation with cardiac and vascular function. Ghrelin is correlated with IL-1β (r = 0.88, p
Databáze: OpenAIRE
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