Naltrexone in autistic children: an acute open dose range tolerance trial
| Autor: | Mae S. Sokol, John E. Overall, Richard Perry, Spencer Ek, Phillip Adams, Kim M. Monti, Rodger L. Foltz, Magda Campbell, Eugene Roberts, Mitchell S. Nobler, Arthur M. Small |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Male
Side effect medicine.diagnostic_test Dose-Response Relationship Drug Sedation Placebo Naltrexone Psychiatry and Mental health Dose–response relationship Anesthesia Child Preschool Developmental and Educational Psychology medicine Humans Psychopharmacology Dosing medicine.symptom Autistic Disorder Stereotyped Behavior Psychology Liver function tests Child medicine.drug |
| Zdroj: | Journal of the American Academy of Child and Adolescent Psychiatry. 28(2) |
| ISSN: | 0890-8567 |
| Popis: | The safety and efficacy of naltrexone was explored in an open acute dose range tolerance trial in 10 hospitalized autistic children, ages 3.42 to 6.50 years (mean, 5.04). Naltrexone was given in ascending doses: 0.5, 1.0, and 2.0 mg/kg/day. Behavioral side effects were observed as early as ½ hour after dosing. Ratings on the Children's Psychiatric Rating Scale showed that withdrawal was reduced across all three dose levels; administration of 0.5 mg/kg/day dose resulted in increased verbal production; and the 2.0 mg/kg/day dose resulted in reduction of stereotypies. Mild sedation of brief duration was the only side effect. Electrocardiogram, liver function tests, and all other laboratory studies remained unchanged throughout the study. These preliminary findings require replication in a larger sample of patients under double-blind and placebo controlled condition. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|