Xin proteins and intercalated disc maturation, signaling and diseases
| Autor: | Jenny Li-Chun Lin, Chung-Jing J Lin, Kuo-Ho Wu, Haley W. Sinn, Qinchuan Wang, Cheng-I Lin, Da-Zhi Wang, Rebecca S. Reiter |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Cardiac function curve
Cell signaling Protein family Heart Diseases Cardiomyopathy Cell Communication Biology Article Ion Channels Mice medicine Myocyte Animals Humans Myocytes Cardiac Heart development Models Cardiovascular Membrane Proteins Nuclear Proteins Catenins medicine.disease Cell biology DNA-Binding Proteins Wnt Proteins medicine.anatomical_structure Intercellular Junctions Signal transduction Intercalated disc Signal Transduction |
| Popis: | Intercalated discs (ICDs) are cardiac-specific structures responsible for mechanical and electrical communication among adjacent cardiomyocytes and are implicated in signal transduction. The striated muscle-specific Xin repeat-containing proteins localize to ICDs and play critical roles in ICD formation and cardiac function. Knocking down the Xin gene in chicken embryos collapses the wall of developing heart chambers and leads to abnormal cardiac morphogenesis. In mammals, a pair of paralogous genes, Xinalpha and Xinbeta exist. Ablation of the mouse Xinalpha (mXinalpha) does not affect heart development. Instead, mXinalpha-deficient mice show adult late-onset cardiac hypertrophy and cardiomyopathy with conduction defects. The mXinalpha-deficient hearts up-regulate mouse Xinbeta (mXinbeta), suggesting a partial compensatory role of mXinbeta. Complete loss of mXinbeta, however, leads to failure of forming ICD, mis-localization of mXinalpha, and early postnatal lethality. In this review, we will briefly discuss recent advances in the anatomy and function of ICDs. We will then review what we know about Xin repeat-containing proteins and how this protein family promotes ICD maturation and stability for normal cardiac function. |
| Databáze: | OpenAIRE |
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