Experimental middle ear surgery in rabbits: A new approach for reconstructing the ossicular chain

Autor: H J Hedrich, Th Lenarz, Martin Stieve, Peter Paul Müller, Battmer Rd, Peter Behrens
Jazyk: angličtina
Rok vydání: 2009
Předmět:
Experimental middle ear surgery
implant
audiometry
Brain response audiometry
Oryctolagus cuniculus
Ossicular chain prostheses
ddc:590
Dewey Decimal Classification::500 | Naturwissenschaften::590 | Tiere (Zoologie)
Auditory ossicle
middle ear reconstruction
Ear Ossicles
experimental animal
Titanium
medicine.diagnostic_test
article
stenosis
Anatomy
eardrum
medicine.anatomical_structure
auditory ossicle
female
Ossicular Replacement
Hearing level
Middle ear
Rabbits
Eardrum
auditory threshold
medicine.medical_specialty
rabbit
middle ear surgery
surgical technique
Statistics
Nonparametric
Bone conduction
medicine
otorhinolaryngologic diseases
erbium YAG laser
Animals
Animalia
controlled study
nonhuman
General Veterinary
Ossicles
business.industry
Surgery
Audiometry
Evoked Response
Ossicular Prosthesis
Animal Science and Zoology
Implant
sense organs
Audiometry
business
Zdroj: Laboratory Animals 43 (2009), Nr. 2
DOI: 10.15488/3005
Popis: This experimental animal study aimed at evaluating a new prosthesis to replace the ossicular chain; we developed a new technique for surgical implantation into the middle ear of rabbits. The rabbit middle ear is, owing to the relative anatomical dimensions involved, an ideal environment for implantation procedures involving the ossicles, as the surgical conditions are similar to those of the human middle ear. This study included a total of 34 approximately six-month-old female white rabbits (New Zealand) weighing between 3.2 and 4.4 kg. The implants used were constructed of ceramic materials (titania, TiO2) of various pore sizes. Directly prior to implanting the total ossicular reconstruction prostheses (TORPs), as well as at 28, 84 and 300 days after implantation, electric response audiometry was used to determine the hearing thresholds of the animals (bone conduction; click stimulus nHL). An erbium:YAG laser was used to excise the original ossicular chain. Following implantation, we were unable to detect any stenosis of the outer ear canal or perforation of the tympanic membrane. The conductive hearing threshold was in the range of 4.21 ± 6.68 dB nHL ( n = 131). The hearing level showed no significant difference before and after surgery ( P < 0.05).
Databáze: OpenAIRE
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