Atypical measures of diffusion at the gray‐white matter boundary in autism spectrum disorder in adulthood
| Autor: | Patrick Bolton, Greg Pasco, Rafael Romero-Garcia, Marco Catani, Michael V. Lombardo, A Madden, Anke Bletsch, Eileen Daly, Patrick G. Johnston, Simon Baron-Cohen, Derek K. Jones, Debbie Spain, Maria Gudbrandsen, Sally Wheelwright, Christine Ecker, Susan A. Sadek, R Stewart, M. Lai, Sarah J. Carrington, D Mullins, Crispian Wilson, Edward T. Bullmore, Tim Schäfer, J Henty, Michael C. Craig, Peter Jezzard, Francesca Happé, Clodagh M. Murphy, Flavio Dell'Acqua, R Dallyn, Steven Williams, Deoni Scl., Ruigrok Anv., Caroline Mann, John Suckling, Derek Sayre Andrews, Murphy Dgm., Bhismadev Chakrabarti, A J Bailey |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Adolescent Autism Spectrum Disorder Boundary (topology) multimodal imaging Neuropathology Biology 050105 experimental psychology White matter Young Adult 03 medical and health sciences 0302 clinical medicine Neuroimaging mental disorders Fractional anisotropy myelinated and unmyelinated gray matter medicine Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Gray Matter Research Articles Radiological and Ultrasound Technology 05 social sciences Brain Middle Aged diffusion tensor imaging medicine.disease White Matter medicine.anatomical_structure Neurology Autism spectrum disorder superficial white matter Female Neurology (clinical) Anatomy Neuroscience 030217 neurology & neurosurgery Neurotypical Research Article Diffusion MRI |
| Zdroj: | Human Brain Mapping |
| ISSN: | 1097-0193 1065-9471 |
| DOI: | 10.1002/hbm.25237 |
| Popis: | Autism spectrum disorder (ASD) is a highly complex neurodevelopmental condition that is accompanied by neuroanatomical differences on the macroscopic and microscopic level. Findings from histological, genetic, and more recently in vivo neuroimaging studies converge in suggesting that neuroanatomical abnormalities, specifically around the gray‐white matter (GWM) boundary, represent a crucial feature of ASD. However, no research has yet characterized the GWM boundary in ASD based on measures of diffusion. Here, we registered diffusion tensor imaging data to the structural T1‐weighted images of 92 adults with ASD and 92 matched neurotypical controls in order to examine between‐group differences and group‐by‐sex interactions in fractional anisotropy and mean diffusivity sampled at the GWM boundary, and at different sampling depths within the superficial white and into the gray matter. As hypothesized, we observed atypical diffusion at and around the GWM boundary in ASD, with between‐group differences and group‐by‐sex interactions depending on tissue class and sampling depth. Furthermore, we identified that altered diffusion at the GWM boundary partially (i.e., ~50%) overlapped with atypical gray‐white matter tissue contrast in ASD. Our study thus replicates and extends previous work highlighting the GWM boundary as a crucial target of neuropathology in ASD, and guides future work elucidating etiological mechanisms. The present study observed atypical diffusion at and around the gray‐white matter (GWM) boundary in individuals with autism spectrum disorder (ASD) relative to neurotypical controls, with between‐group differences and group‐by‐sex interactions depending on tissue class and sampling depth. Altered diffusion at the GWM boundary was further identified to partially (i.e., ~50%) and nonrandomly overlap with atypical gray‐white matter tissue contrast in ASD. The study thus replicates and extends previous work highlighting the GWM boundary as a crucial target of neuropathology in ASD, and guides future work elucidating etiological mechanisms. |
| Databáze: | OpenAIRE |
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