RADIOIMMUNE ASSAY OF HETEROLOGOUS SERUM γ-GLOBULIN IN PATIENTS RECEIVING RABBIT ANTIHUMAN THYMOCYTE GLOBULIN
| Autor: | Philip E. Oyer, Edward B. Stinson, Lyle A. David, Charles P. Bieber, Eva Lydick, Randall B. Griepp |
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| Rok vydání: | 1975 |
| Předmět: |
medicine.medical_specialty
Time Factors Globulin T-Lymphocytes medicine.medical_treatment Radioimmunoassay Heterologous Antigen Antigens Heterophile Internal medicine medicine Animals Humans Transplantation Homologous Antigens Antilymphocyte Serum Heart transplantation Transplantation Sheep biology business.industry Antibody titer Gamma globulin Hemagglutination Tests Antibodies Anti-Idiotypic Endocrinology Antibody Formation biology.protein Heart Transplantation Rabbits gamma-Globulins Antibody business |
| Zdroj: | Transplantation. 20:393-398 |
| ISSN: | 0041-1337 |
| DOI: | 10.1097/00007890-197511000-00006 |
| Popis: | A radioimmune assay (RIA) method for detecting heterologous serum rabbit gamma-globulin (RG) and antibody to this protein is described. The methodology is used for monitoring serum levels of rabbit globulin in patients receiving rabbit ATG (RATG). In 7 cardiac recipients receiving RATG, maximum serum levels of RG were achieved 1-3 days after administration of final dose. RG half-life subsequent to peak serum levels was rapid (X = 36 hr) in 4 patients and prolonged (X = 18 days) in 3 patients. Patient antibody to rabbit gamma-globulin was detectable only in those patients with short RG half-life. Antirabbit antibody titers in these patients were extremely low and barely detectable by RIA. |
| Databáze: | OpenAIRE |
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