Transcriptional Characterization of Stage I Epithelial Ovarian Cancer: A Multicentric Study
| Autor: | Germana Tognon, Andrea Sambugaro, Giuseppe Benvenuto, Flaminia Zane, Matteo Ciciani, Robert Fruscio, Martina Delle Marchette, Sergio Marchini, Chiara Romualdi, Antonella Ravaggi, Eliana Bignotti, Fulvio Borella, Salvatore Milite, Luca Beltrame, Paolo Martini, Franco Odicino, Lara Paracchini, Maurizio D'Incalci, Dionyssios Katsaros, Enrica Calura |
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| Přispěvatelé: | Calura, E, Ciciani, M, Sambugaro, A, Paracchini, L, Benvenuto, G, Milite, S, Martini, P, Beltrame, L, Zane, F, Fruscio, R, Marchette, M, Borella, F, Tognon, G, Ravaggi, A, Katsaros, D, Bignotti, E, Odicino, F, D'Incalci, M, Marchini, S, Romualdi, C |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Transcription
Genetic endocrine system diseases In silico pathways Carcinoma Ovarian Epithelial Biology Molecular heterogeneity Article Immune system Gene expression Biomarkers Tumor Humans Gene Regulatory Networks Epithelial ovarian cancer gene expressions cancer histotypes stage I ovarian cancer Gene Neoplasm Staging cancer histotype Ovarian Neoplasms pathway Gene Expression Profiling General Medicine female genital diseases and pregnancy complications Gene Expression Regulation Neoplastic Serous fluid gene expression Cancer research Female Neoplasm Grading Metabolic Networks and Pathways Clear cell Signal Transduction |
| Zdroj: | Cells Volume 8 Issue 12 |
| Popis: | Stage I epithelial ovarian cancer (EOC) represents about 10% of all EOCs. It is characterized by a complex histopathological and molecular heterogeneity, and it is composed of five main histological subtypes (mucinous, endometrioid, clear cell and high, and low grade serous), which have peculiar genetic, molecular, and clinical characteristics. As it occurs less frequently than advanced-stage EOC, its molecular features have not been thoroughly investigated. In this study, using in silico approaches and gene expression data, on a multicentric cohort composed of 208 snap-frozen tumor biopsies, we explored the subtype-specific molecular alterations that regulate tumor aggressiveness in stage I EOC. We found that single genes rather than pathways are responsible for histotype specificities and that a cAMP-PKA-CREB1 signaling axis seems to play a central role in histotype differentiation. Moreover, our results indicate that immune response seems to be, at least in part, involved in histotype differences, as a higher immune-reactive behavior of serous and mucinous samples was observed with respect to other histotypes. |
| Databáze: | OpenAIRE |
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