Pancreatic beta cells are important targets for the diabetogenic effects of glucocorticoids
| Autor: | Arne Andersson, Suad Efendic, Behrous Davani, Franck Delaunay, Jan-Ake Gustafsson, Claes-Göran Östenson, Sam Okret, Antonio Cintra, Zong Chao Ling, Akhtar Khan |
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| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Glucose uptake medicine.medical_treatment Mice Transgenic Biology Dexamethasone Islets of Langerhans Mice Receptors Glucocorticoid Glucocorticoid receptor Diabetes mellitus Internal medicine medicine Animals Insulin Glucocorticoids Glucose tolerance test medicine.diagnostic_test General Medicine Glucose Tolerance Test medicine.disease Immunohistochemistry Insulin oscillation Glucose Endocrinology Diabetes Mellitus Type 2 Beta cell Research Article Hormone |
| Zdroj: | Journal of Clinical Investigation. 100:2094-2098 |
| ISSN: | 0021-9738 |
| Popis: | Abnormalities contributing to the pathogenesis of non-insulin-dependent diabetes mellitus include impaired beta cell function, peripheral insulin resistance, and increased hepatic glucose production. Glucocorticoids are diabetogenic hormones because they decrease glucose uptake and increase hepatic glucose production. In addition, they may directly inhibit insulin release. To evaluate that possible role of glucocorticoids in beta cell function independent of their other effects, transgenic mice with an increased glucocorticoid sensitivity restricted to their beta cells were generated by overexpressing the glucocorticoid receptor (GR) under the control of the insulin promoter. Intravenous glucose tolerance tests showed that the GR transgenic mice had normal fasting and postabsorptive blood glucose levels but exhibited a reduced glucose tolerance compared with their control littermates. Measurement of plasma insulin levels 5 min after intravenous glucose load demonstrated a dramatic decrease in acute insulin response in the GR transgenic mice. These results show that glucocorticoids directly inhibit insulin release in vivo and identify the pancreatic beta cell as an important target for the diabetogenic action of glucocorticoids. |
| Databáze: | OpenAIRE |
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