Atorvastatin Combining with Probucol: A New Way to Reduce Serum Uric Acid Level during Perioperative Period of Interventional Procedure
| Autor: | Hongliang Cong, Hong Li, Hongjun Ma, Ximing Li, Yi-ran Wang, Dong-xia Jin, Naikuan Fu |
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| Rok vydání: | 2014 |
| Předmět: |
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Atorvastatin Contrast Media lcsh:Medicine Kidney Function Tests lcsh:Technology Antioxidants chemistry.chemical_compound Risk Factors Prospective Studies lcsh:Science Blood urea nitrogen General Environmental Science Acute kidney injury General Medicine Acute Kidney Injury Middle Aged Hypertension Drug Therapy Combination Female medicine.drug medicine.medical_specialty Article Subject Urology Probucol Renal function General Biochemistry Genetics and Molecular Biology medicine Humans Pyrroles Perioperative Period Aged Creatinine lcsh:T business.industry lcsh:R Perioperative medicine.disease Uric Acid Surgery chemistry Heptanoic Acids Clinical Study Uric acid lcsh:Q Hydroxymethylglutaryl-CoA Reductase Inhibitors business Biomarkers |
| Zdroj: | The Scientific World Journal, Vol 2014 (2014) The Scientific World Journal |
| ISSN: | 1537-744X 2356-6140 |
| DOI: | 10.1155/2014/565367 |
| Popis: | Uric acid has ever been considered as one of contrast induced acute kidney injury’s risk factors. Atorvastatin and probucol can both improve contrast induced acute kidney injury separately. This prospective study is to assess their effect on reducing serum uric acid level and contrast induced acute kidney injury during perioperative period of interventional procedure. On the basis of different doses of atorvastatin and probucol, 208 cases admitted for coronary angiography or percutaneous coronary intervention were randomly classified into standard combined group (S-C group), intensive combined group (I-C group), and intensive atorvastatin group (I-A group). Patients’ blood urea nitrogen, serum creatinine, and serum uric acid were measured and estimated glomerular filtration rate was evaluated 24 hours before and after the procedure. After procedure, blood urea nitrogen in all the three groups decreased; Scr of S-C group and I-A group increased significantly, while estimated glomerular filtration decreased in the S-C group (P<0.05); serum uric acid in S-C group and I-C group decreased significantly (P<0.05). Combination treatment of atorvastatin and probucol before intervention could reduce perioperative serum uric acid level; meanwhile, the intensive combined treatment can improve the contrast induced acute kidney injury. The result was the same for hypertensive patients. |
| Databáze: | OpenAIRE |
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