Two Independent Clones in Myelodysplastic Syndrome Following Treatment of Acute Myeloid Leukemia
| Autor: | Hirohito Suzuki, Koichi Inagaki, Nobuyuki Minami, Naoyuki Katayama, Hidetsugu Mitani, Shinichi Kageyama, Natsuki Hoshino, Hiroto Araki, Masahiro Masuya, Kazuhiro Nishii, Hiroshi Miwa, Hiroshi Shiku, Hiroyuki Miyashita |
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| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Pathology medicine.medical_treatment Antineoplastic Agents Biology Gastroenterology Translocation Genetic hemic and lymphatic diseases Internal medicine medicine Humans neoplasms Chemotherapy Chromosomes Human Pair 12 Hematology medicine.diagnostic_test Chromosomes Human Pair 11 Cytogenetics Myeloid leukemia Neoplasms Second Primary Middle Aged medicine.disease Clone Cells Bone marrow examination Leukemia medicine.anatomical_structure Chromosomes Human Pair 1 Leukemia Myeloid Dysplasia Chromosomes Human Pair 2 Myelodysplastic Syndromes Acute Disease Cytogenetic Analysis Female Bone marrow |
| Zdroj: | International Journal of Hematology. 75:182-186 |
| ISSN: | 1865-3774 0925-5710 |
| Popis: | We describe a 55-year-old Japanese woman with therapy-related myelodysplastic syndrome (t-MDS) with 2 independent clones, t(1;2)(p36;p21) and t(11;12)(pl5;ql3). She was diagnosed with acute myeloid leukemia (AML) with cytological features of the bone marrow and peripheral blood. Cytogenetic evaluation revealed a 46,XX karyotype. She received chemotherapy and achieved complete remission (CR). Despite maintenance chemotherapy, she suffered a relapse. Chromosomal analysis showed t(1;2)(p36;p21) in 2 of 20 metaphases. At second CR, this clone transiently disappeared. Nine months later, t(1;2) (p36;p21) was detected again in 3 of 20 metaphases while the patient remained in CR. Six months later, bone marrow examination disclosed trilineage dysplasia without an excess of blasts, suggesting MDS. t(1;2)(p36;p21) was observed in 16 of 20 metaphases. The clinical course and serial cytogenetic findings were diagnostic of t-MDS. The duration of t-MDS was 6 years. During this period, persistent t(1;2)(p36;p21) and transient t(11;12)(p15;q13) were found. When t-MDS evolved toAML, cytogenetic evaluation revealed 46,XX,t(1;2)(p36;p21),del(7)(q22),add(19)(p13). |
| Databáze: | OpenAIRE |
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