Intravitreal bevacizumab associated with grid laser photocoagulation in macular edema secondary to branch retinal vein occlusion
Autor: | L.M. Sádaba-Echarri, Javier Zarranz-Ventura, Angel Salinas-Alamán, Jose M. Caire González-Jauregui, Alfredo García-Layana, Jesús Barrio-Barrio |
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Jazyk: | angličtina |
Rok vydání: | 2011 |
Předmět: |
Male
Vascular Endothelial Growth Factor A Visual acuity genetic structures Visual Acuity Angiogenesis Inhibitors 0302 clinical medicine Antibodies monoclonal humanized/administration and dosage Fluorescein Angiography Fisher's exact test Aged 80 and over Laser Coagulation medicine.diagnostic_test General Medicine Middle Aged Combined Modality Therapy Bevacizumab Treatment Outcome Intravitreal Injections Retreatment symbols Female medicine.symptom Tomography Optical Coherence medicine.drug medicine.medical_specialty Antibodies Monoclonal Humanized Macular Edema Retina Angiogenesis inhibitors/administration and dosage 03 medical and health sciences symbols.namesake Optical coherence tomography Ophthalmology Retinal Vein Occlusion medicine Humans Symptom onset Intravitreal bevacizumab Macular edema Aged business.industry medicine.disease eye diseases 030221 ophthalmology & optometry Branch retinal vein occlusion sense organs business 030217 neurology & neurosurgery |
Zdroj: | Dadun. Depósito Académico Digital de la Universidad de Navarra instname |
Popis: | To evaluate intravitreal bevacizumab (IVB) combined with grid laser photocoagulation in macular edema (ME) secondary to branch retinal vein occlusion (BRVO). METHODS: Eight eyes (8 patients) with ME associated with BRVO with at least 3 months of evolution since symptom onset were included. All subjects underwent measurement of best-corrected visual acuity (BCVA) and imaging with spectral domain optical coherence tomography (SD-OCT) at baseline and 1, 3, 6, and 12 months. Intravitreal bevacizumab was administered at baseline and macular grid laser photocoagulation 1 month later. During follow-up, additional IVB was administered based on physician discretion if persistent or recurrent intraretinal fluid (cysts) was observed on SD-OCT. The mean BCVA and SD-OCT central subfield thickness (CST) values were determined at each time point. Fisher exact test was performed to assess differences between baseline and post-treatment BCVA and SD-OCT measurements. RESULTS: The mean baseline BCVA was 0.28+/-0.14 (mean+/-SD), and the mean CST was 479+/-137 microm. The mean BCVAs at 1, 3, 6, and 12 months were 0.47+/-0.18 (p=0.031), 0.56+/-0.50 (p=0.031), 0.65+/-0.60 (p=0.008), and 0.66+/-0.65 (p=0.016), respectively. The mean CST values at 1, 3, 6, and 12 months were 295+/-60 microm (p=0.008), 333+/-114 microm (p=0.070), 339+/-80 microm (p=0.008), and 335+/-109 microm (p=0.008). A mean 2.13 injections were administered; the second injection was administered a mean of 2.71 months after baseline. CONCLUSIONS: Combined treatment with IVB and macular grid photocoagulation provided good results and may be considered as an alternative therapy for ME in BRVO. Further studies are needed to assess these preliminary results. |
Databáze: | OpenAIRE |
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