Recovery of human skin impedance in vivo after iontophoresis: Effect of metal ions
| Autor: | Curdy, C., Yogeshvar Kalia, Falson-Rieg, F., Guy, R. H. |
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| Předmět: |
Adult
Sodium Chloride/pharmacology Metal ions in aqueous solution Inorganic chemistry Analytical chemistry Magnesium Chloride Pharmaceutical Science Ionic bonding Human skin Electrolyte Sodium Chloride Metals/pharmacology Article Ion Potassium Chloride Calcium Chloride Potassium Chloride/pharmacology Cations Skin Physiological Phenomena Electric Impedance Humans Magnesium Chloride/pharmacology ddc:615 Aqueous solution Iontophoresis Chemistry Skin Physiological Phenomena/drug effects Osmolar Concentration Ionic strength Metals Calcium Chloride/pharmacology |
| Zdroj: | Scopus-Elsevier AAPS PharmSci, Vol. 2, No 3 (2000) P. E23 |
| ISSN: | 1522-1059 |
| Popis: | The objective of this study was to investigate the effect of the counter-ion (cation) on the recovery of human skin impedance after iontophoresis in vivo. A series of metal chloride aqueous solutions (NaCl, KCl, CaCl2, and MgCl2) was investigated: first at the same concentration (133 mmol/L) and then at the same ionic strength as a NaCl solution at 133 mmol/L. The influence of hydration alone was also examined as a control. The recovery of human skin impedance was followed in the frequency range 1-1,000 Hz, over a 30-minute period after iontophoresis during which 3 impedance spectra were recorded. The results revealed that at t = 30 minutes post-iontophoresis, skin impedance was approximately 3 times greater than the value immediately after the cessation of current passage. However, the results showed that the nature of the cation had no effect on recovery, regardless of whether the ions were at the same concentration or at an equivalent ionic strength. A simple parallel RC-equivalent circuit model for skin was used to determine the resistive (R) and capacitive (C) contributions to skin impedance. An analysis of variance on the calculated R and C values did not show any differences between the electrolytes used at the 2 different ionic strengths. |
| Databáze: | OpenAIRE |
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