Electrical and mechanical alternans during ventricular tachycardia with moderate chronic heart failure
| Autor: | Steven Goldman, Ikeotunye Royal Chinyere, Elizabeth Juneman, Talal Moukabary |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
Tachycardia Electrical alternans medicine.medical_specialty Cardiomyopathy 030204 cardiovascular system & hematology Ventricular tachycardia Rats Sprague-Dawley Electrocardiography 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Animals cardiovascular diseases 030212 general & internal medicine Heart Failure medicine.diagnostic_test Cardiac electrophysiology business.industry Pulse (signal processing) medicine.disease Biomechanical Phenomena Electrophysiological Phenomena Rats Disease Models Animal Heart failure Anesthesia Chronic Disease Tachycardia Ventricular cardiovascular system Cardiology medicine.symptom Cardiology and Cardiovascular Medicine business human activities |
| Zdroj: | Journal of Electrocardiology. 51:33-37 |
| ISSN: | 0022-0736 |
| DOI: | 10.1016/j.jelectrocard.2017.09.002 |
| Popis: | A chronic heart failure (CHF) rat underwent epicardial programmed electrical stimulation (PES). Ventricular tachycardia (VT) developed during PES. Mechanical alternans was noted despite fixed tachycardia cycle length. Anti-tachycardia pacing attempts initiated a second VT that generated pulse intermittently and then degenerated into pulseless VT with electrical alternans.To our knowledge electrical and mechanical alternans have not been recorded in animal models of CHF during VT. The distinct events of mechanical alternans and electrical alternans may be indicative of progressively worsened calcium handling in the compromised cardiomyocytes.Although ion channel differences between rodents and humans exist, this work attempts to demonstrate this rat model's usefulness in understanding cardiac electrophysiology in CHF. |
| Databáze: | OpenAIRE |
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