Association Between Polymorphisms in COMT, PLCH1, and CYP17A1, and Non–Small-Cell Lung Cancer Risk in Chinese Nonsmokers
| Autor: | Yongjun Zhang, Bao Wenlong, Shi Hua, Dehou Deng, Aiqin Zhang, Chuming Jiang, Xiangming Kong |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Oncology China Cancer Research medicine.medical_specialty Lung Neoplasms Genotype Population Single-nucleotide polymorphism Adenocarcinoma Catechol O-Methyltransferase Bioinformatics Polymorphism Single Nucleotide Phosphoinositide Phospholipase C Asian People Risk Factors Carcinoma Non-Small-Cell Lung Internal medicine Confidence Intervals Odds Ratio medicine Humans SNP Lung cancer education Genotyping Aged Aged 80 and over education.field_of_study Chi-Square Distribution business.industry Smoking Steroid 17-alpha-Hydroxylase Odds ratio Middle Aged medicine.disease Case-Control Studies Carcinoma Squamous Cell Female business rs4680 |
| Zdroj: | Clinical Lung Cancer. 14:45-49 |
| ISSN: | 1525-7304 |
| Popis: | Background Recently, polymorphisms in COMT (catechol-O-methyltransferase), PLCH1 (phosphoinositide-specific phospholipase C eta 1), and CYP17A1 (cytochrome P450 17A1 ) were found to be associated with the development of lung cancer in a non-Chinese population. Aims To explore the potential association between single-nucleotide polymorphism (SNP) in COMT , PLCH1 , CYP17A1, and non–small-cell lung cancer (NSCLC) susceptibility in Chinese patients who were nonsmokers. Methods A case-controlled study was conducted in 200 patients with NSCLC and 200 healthy controls who were age and sex matched. SNPs rs4680, rs181696, and rs743572 from the COMT , PLCH1 , and CYP17A1 genes, respectively, were selected for genotyping. The association between genotype and lung cancer risk was evaluated by computing the odds ratio and 95% confidence interval from multivariate unconditional logistic regression analyses with adjustment for sex and age. Results The frequency of the G genotype in COMT rs4680 was statistically different between patients with NSCLC and controls ( P = .04), and between patients with adenocarcinomas (ADC) and controls ( P = .02). The frequency of the A genotype in PLCH1 rs181696 occurred more frequently in squamous cell carcinomas (SQC) than in controls ( P = .02). The G/G homozygous genotype in COMT rs4680 and A/A homozygous genotype in PLCH1 rs181696 were associated with ADC and SQC, respectively (odds ratio [OR] 0.61 and OR 2.01, respectively). Conclusion In this study, we found that the COMT rs4680 SNP was significantly associated with a reduced risk of NSCLC, especially ADC, which suggests that this SNP may have a protective effect. Moreover, the PLCH1 rs181696 SNP was strongly associated with an increased risk of SQC, which suggests that this SNP may be a risk factor for developing SQC. |
| Databáze: | OpenAIRE |
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