Defining visual illusions in Parkinson's disease: Kinetopsia and object misidentification illusions
| Autor: | Miyeong Gang, Yoshiyuki Nishio, Makoto Uchiyama, Yoshiyuki Hosokai, Kazumi Hirayama, Kayoko Yokoi, Atsushi Takeda, Etsuro Mori, Toshiyuki Ishioka, Toru Baba, Kyoko Suzuki |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Hallucinations genetic structures media_common.quotation_subject Illusion Neuropsychological Tests Audiology 03 medical and health sciences 0302 clinical medicine Fluorodeoxyglucose F18 Surveys and Questionnaires medicine Humans Aged media_common Aged 80 and over Neural correlates of consciousness Optical illusion Cognitive neuroscience of visual object recognition Neuropsychology Parkinson Disease Middle Aged Illusions Magnetic Resonance Imaging Object (philosophy) Visual Hallucination 030104 developmental biology Visual cortex medicine.anatomical_structure Neurology Positron-Emission Tomography Female Neurology (clinical) Geriatrics and Gerontology Mental Status Schedule Psychology 030217 neurology & neurosurgery |
| Zdroj: | Parkinsonism & Related Disorders. 55:111-116 |
| ISSN: | 1353-8020 |
| Popis: | Objective To identify the phenomenological features and neural correlates of visual illusions in Parkinson's disease (PD). Methods Ninety-three patients with PD were assessed via questionnaires regarding visual illusions and behavioral symptoms, and neuropsychological tests, motor assessments and 18-F fluorodeoxyglucose-positron emission tomography (FDG-PET) were performed. The relationship between visual illusions or hallucinations and regional cerebral glucose metabolism was investigated using partial least squares (PLS) correlation and conventional mass-univariate analyses. Results Kinetopsia, in which stationary objects are perceived as being in motion, and object misidentification illusions, in which objects are misperceived as different objects, were the most common types of visual illusions. Kinetopsia and object misidentification illusions were identified in 24 patients (25.8%) and 17 patients (18.3%), respectively. Eleven patients with kinetopsia and 9 patients with object misidentification illusions had visual hallucinations. Kinetopsia and visual hallucinations were associated with hypometabolism in the temporo-parietal cortices, whereas object misidentification illusions were associated with hypometabolism in the early visual cortex, as well as the temporo-parietal cortices. Conclusions Our findings suggest that kinetopsia and object misidentification illusions are the most common types of visual illusions in PD. Despite the phenomenological diversity of visual illusions and hallucinations in PD, all of these symptoms are associated with dysfunction of the temporo-parietal cortices, which support visual spatial processing, rather than dysfunction of the ventral temporo-occipital cortices, which supports visual object recognition. |
| Databáze: | OpenAIRE |
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