Short- and long-term effects of body weight loss following calorie restriction and gastric bypass on CYP3A-activity – a non-randomized three-armed controlled trial
| Autor: | Hege Christensen, Veronica Krogstad, Philip Carlo Angeles, Anders Åsberg, Ida Robertsen, Kine Eide Kvitne, Rasmus Jansson-Löfmark, Kristine Hole, Per Artursson, Rune Sandbu, Shalini Andersson, Christine Wegler, Line Kristin Johnson, Birgit M Wollmann, Jøran Hjelmesæth, Eva Skovlund, Tommy B. Andersson, Cecilia Karlsson |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty CYP3A Midazolam Calorie restriction Gastric Bypass RM1-950 Overweight Gastroenterology General Biochemistry Genetics and Molecular Biology Article law.invention Pharmaceutical Sciences Pharmacokinetics Randomized controlled trial law Weight loss Internal medicine Weight Loss medicine Cytochrome P-450 CYP3A Humans Hypnotics and Sedatives Dosing General Pharmacology Toxicology and Pharmaceutics Caloric Restriction business.industry Kirurgi General Neuroscience Research nutritional and metabolic diseases General Medicine Articles Middle Aged Farmaceutiska vetenskaper Surgery Female Therapeutics. Pharmacology medicine.symptom Public aspects of medicine RA1-1270 business medicine.drug |
| Zdroj: | Clinical and Translational Science (CTS) Clinical and Translational Science Clinical and Translational Science, Vol 15, Iss 1, Pp 221-233 (2022) |
| ISSN: | 1752-8054 |
| Popis: | It remains uncertain whether pharmacokinetic changes following Roux‐en‐Y gastric bypass (RYGB) can be attributed to surgery‐induced gastrointestinal alterations per se and/or the subsequent weight loss. The aim was to compare short‐ and long‐term effects of RYGB and calorie restriction on CYP3A‐activity, and cross‐sectionally compare CYP3A‐activity with normal weight to overweight controls using midazolam as probe drug. This three‐armed controlled trial included patients with severe obesity preparing for RYGB (n = 41) or diet‐induced (n = 41) weight‐loss, and controls (n = 18). Both weight‐loss groups underwent a 3‐week low‐energy‐diet ( |
| Databáze: | OpenAIRE |
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