Prognostic role of baseline neutrophil-to-lymphocyte ratio in metastatic solid tumors

Autor: Pawel Karwowski, Amanda Zucker, Alex Winter, Johnny Kao, Min‑kyung Jung, Dean Lumley
Rok vydání: 2019
Předmět:
Zdroj: Mol Clin Oncol
ISSN: 2049-9450
Popis: High baseline neutrophil-to-lymphocyte ratio (NLR) has been associated with poor survival in a number of solid tumors, but has not been extensively investigated in the context of radiation oncology. Developing more robust models to predict survival would inform patient care for patients with metastatic solid tumors. The present study was undertaken to evaluate the effect of baseline NLR (using 4 as a cutoff) on survival in 320 consecutive patients with metastatic cancer who were referred to a single radiation oncologist between 2012 and 2015, with a median follow-up of 20.6 months. The median NLR was 4.4 (interquartile range, 2.8-7.2). Patients with a baseline NLR ≤4 had a median survival of 9.3 months compared to 4.1 months for NLR >4 (P4 independently predicted adverse survival in this cohort.
Databáze: OpenAIRE