| Autor: |
Yoshiaki Ito, Jean-Paul Thiery, GV Shivashankar, Dominic C. Voon, Linda Shyue Huey Chuang, Amudha Ganesan, Doorgesh S. Jokhun, Haresh Sankar, Lavina Sierra Tay, Muhammad Bakhait Bin Rahmat, Madhura Kulkarni, Tuan Zea Tan, Yu Lin Chong, Vaidehi Krishnan |
| Rok vydání: |
2023 |
| DOI: |
10.1158/0008-5472.22417427 |
| Popis: |
This file contains Supplementary Figures 1-8. Fig.S1 shows Characterization of TGF-β-dependent EMT. Fig.S2 shows an analysis of endogenous DNA damage accumulation in the presence of TGF-β. Fig.S3 shows the Upregulation of NOX4 and downregulation of NRF-dependent genes upon TGF-β exposure.Fig.S4 displays that RNA-sequencing analysis unveils spontaneous EMT upon RUNX3 knockdown. Fig.S5 shows the regulation of HMOX1 expression by RUNX3. Figure.S6 shows how BACH1-KD in RUNX3-depleted cells rescues the accumulation of DNA damage. Fig.S7 displays RUNX1 depletion results in DNA damage accumulation and senescence in the presence of TGF-β. Fig.S8 shows HMOX1 depletion results in heightened ROS production and senescence in the presence of TGF-β. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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