Anti-curare effect of plasma from patients with thermal injury
| Autor: | George G. Bierkamper, J. A. Jeevendra Martyn, R. J. Storella |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Diaphragm Drug Resistance Neuromuscular Junction Tubocurarine Drug resistance In Vitro Techniques General Biochemistry Genetics and Molecular Biology Internal medicine Blood plasma Medicine Potency Animals Humans Pancuronium General Pharmacology Toxicology and Pharmaceutics Neuromuscular Blockade Thermal injury business.industry Biological activity General Medicine Rats Phrenic Nerve Curare Endocrinology Female business Burns Neuromuscular Blockers medicine.drug Muscle Contraction Neuromuscular Nondepolarizing Agents |
| Zdroj: | Life sciences. 43(1) |
| ISSN: | 0024-3205 |
| Popis: | Following severe thermal injury, patients are resistant to non-depolarizing muscle relaxants. Although this resistance has been well documented clinically, little is known about its etiology. We have tested the hypothesis that circulating factors contribute to the decreased potency of neuromuscular blockers following burns. The potencies of d-tubocurarine (2 microM) or pancuronium (2 microM) dissolved in plasma from either burned or control human subjects were tested on the indirectly stimulated (0.2 Hz) rat phrenic nerve-hemidiaphragm preparation. The muscle relaxants produced less neuromuscular blockade when dissolved in plasma from burned patients than when they were dissolved in plasma from controls. Thus, circulating factors are involved in the decreased potency of non-depolarizing neuromuscular blocking drugs. |
| Databáze: | OpenAIRE |
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