Hemodynamic and humoral responses to enalapril and nifedipine in the rat
| Autor: | M E Vincent, K Shepley, Roger K. Ferguson, B N Swanson |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Male
medicine.medical_specialty Nifedipine Hemodynamics Blood Pressure Plasma renin activity Renin-Angiotensin System Spontaneously hypertensive rat Enalapril Heart Rate Internal medicine Rats Inbred SHR Internal Medicine medicine Animals Antihypertensive Agents biology business.industry Angiotensin-converting enzyme Dipeptides Rats Kinetics Endocrinology Blood pressure ACE inhibitor biology.protein business medicine.drug |
| Zdroj: | Clinical and experimental hypertension. Part A, Theory and practice. 6(8) |
| ISSN: | 0730-0077 |
| Popis: | The hemodynamic and humoral effects of enalapril, an angiotensin converting enzyme (ACE) inhibitor, and nifedipine, a calcium-entry blocker, were evaluated in conscious spontaneously hypertensive rats (SHR). Rats received enalapril (5 mg/kg, po) or vehicle, followed in one hour by nifedipine (2.5 mg/kg, ip) or its vehicle. After treatment with enalapril alone, systolic blood pressure (BP) declined over a 3 hour period from 204 +/- 4 (mean +/- SE) to 168 +/- 6 mm Hg and remained suppressed for an additional 4 hours. Heart rate (HR) did not change. Plasma renin activity (PRA) increased approximately 9-fold and serum ACE was maximally inhibited. BP response to nifedipine was more rapid, greater in magnitude (-59 +/- 6 mm Hg) and shorter in duration; heart rate increased and remained elevated for 2.5 hours. PRA only rose two-fold. After the drugs in combination, BP declined as rapidly and to the same degree as after nifedipine and remained reduced for a longer duration. Treatment with enalapril attenuated the reflex tachycardia observed after nifedipine. These data suggest that coadministration of an ACE inhibitor and calcium-entry blocker may provide better blood pressure control than either drug class alone and at the same time prevent the reflex tachycardia frequently observed after nifedipine. |
| Databáze: | OpenAIRE |
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