Cross-Sectional Study to Evaluate Factors Associated with Adherence to Antiretroviral Therapy by Brazilian HIV-Infected Patients
| Autor: | Florin Vaida, Fabio S. Amorin, Roberto Badaró, Robert T. Schooley, Rosa Garcia, André Ramos, Carlos Brites, Márcio de Oliveira Silva, Eduardo Martins Netto |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Cross-sectional study Immunology Salvage therapy HIV Infections Treatment Refusal Acquired immunodeficiency syndrome (AIDS) Predictive Value of Tests Virology Internal medicine Antiretroviral Therapy Highly Active Surveys and Questionnaires medicine Humans Treatment Failure Sida biology business.industry Middle Aged Viral Load biology.organism_classification medicine.disease Surgery Regimen Infectious Diseases Cross-Sectional Studies Anti-Retroviral Agents Predictive value of tests HIV-1 Patient Compliance Female Viral disease business Viral load Brazil |
| Zdroj: | Repositório Institucional da UFBA Universidade Federal da Bahia (UFBA) instacron:UFBA |
| DOI: | 10.1089/aid.2006.22.1248 |
| Popis: | p.1248–1252 Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-06-17T12:34:42Z No. of bitstreams: 1 aid.2006.22.pdf: 126417 bytes, checksum: 663103b2e67ef1be722e22478b1b254d (MD5) Rejected by Rodrigo Meirelles (rodrigomei@ufba.br), reason: on 2013-11-14T13:33:32Z (GMT) Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-11-18T12:19:33Z No. of bitstreams: 1 aid.2006.22.pdf: 126417 bytes, checksum: 663103b2e67ef1be722e22478b1b254d (MD5) Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-18T21:03:42Z (GMT) No. of bitstreams: 1 aid.2006.22.pdf: 126417 bytes, checksum: 663103b2e67ef1be722e22478b1b254d (MD5) Made available in DSpace on 2013-11-18T21:03:43Z (GMT). No. of bitstreams: 1 aid.2006.22.pdf: 126417 bytes, checksum: 663103b2e67ef1be722e22478b1b254d (MD5) Previous issue date: 2006 Antiretroviral therapy success is highly dependent on the ability of the patient to fully adhere to the prescribed treatment regimen. We present the results of a cross-sectional study that evaluates the predictive value of a self-administered questionnaire of adherence to antiretroviral (ARV) therapy. Study participants were interviewed using a 36-item Patient Medication Adherence Questionnaire (PMAQ) designed to assess knowledge about ARV therapy, motivation to adhere to treatment, and behavioral skills. Plasma HIV-1 RNA levels were correlated with the results obtained from the PMAQ. Of the 182 study participants, 82 (45%) were receiving their initial ARV regimen. Of the remaining patients, 39 (21%) and 61 (34%) were on a second or additional ARV regimen, respectively. An undetectable viral load was documented in 47/62 (76%) patients on their first regimen who reported missing medication on less than 4 days in the last 3 months. The PMAQ had a higher predictive value of plasma viral suppression for patients in the initial regimen than for patients in salvage therapy. The overall predictive value of the PMAQ to identify adherence was 74%, and 59% for nonadherence, with an overall efficacy of 64%. Of the 74 patients (45%) who did not understand the concept of antiretroviral therapy, 80% were failing or had previously failed the ARV treatment. Of 35 patients with doubts about their HIV status or skeptical of the benefits of ARV therapy, 29 (84%) were nonadherent. Despite the positive predictive value of PMAQ in identifying adherence, self-reported adherence is not a sufficiently precise predictor of treatment success to substitute for viral load monitoring. On the other hand, the use of such an instrument to identify factors associated with nonadherence provides an excellent opportunity to apply early intervention designed to specifically address factors that might be contributing to the lack of adherence prior to regimen failure. |
| Databáze: | OpenAIRE |
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