Procalcitonin and C-reactive protein as markers of infection in systemic lupus erythematosus: the controversy continues
| Autor: | Lobna A. Maged, N M Ibrahim, Hania S. Zayed, E El-Serougy |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Adolescent Procalcitonin Young Adult 03 medical and health sciences 0302 clinical medicine Rheumatology Humans Lupus Erythematosus Systemic Medicine Prospective Studies 030203 arthritis & rheumatology biology business.industry C-reactive protein 030208 emergency & critical care medicine Bacterial Infections Middle Aged C-Reactive Protein Immunology biology.protein Female business Biomarkers |
| Zdroj: | Lupus. 28:1329-1336 |
| ISSN: | 1477-0962 0961-2033 |
| DOI: | 10.1177/0961203318777101 |
| Popis: | Objective The objective of this paper is to investigate the utility of serum procalcitonin (PCT) and C-reactive protein (CRP) as markers of infection in systemic lupus erythematosus (SLE) patients. Patients and methods Sixty-nine SLE patients with symptoms and signs of infection proved by culture and/or a favorable response to antibiotics and 69 SLE patients without infection were included. Serum PCT and plasma high-sensitivity CRP were assessed by an enzyme-linked immunosorbent assay. Results SLE patients with infection had a significantly higher level of CRP than those without infection ((median (IQR) 104.5 (25.5–100.9) and 10.3 (5.4–23.1) mg/l, respectively), pConclusion Serum PCT could not differentiate SLE patients with or without bacterial infection in this study, while the utility of CRP as a marker of infection has been confirmed. |
| Databáze: | OpenAIRE |
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