Mixed-gas model for predicting decompression sickness in rats
| Autor: | R. S. Lillo, E. C. Parker |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty Physiology Decompression Diving Models Biological Noble Gases Global model Rats Sprague-Dawley Decompression sickness Animal model Physiology (medical) medicine Animals Inert gas Likelihood Functions Pulmonary Gas Exchange Mixed gas Decompression Sickness medicine.disease Rats Surgery Oxygen Anesthesia Environmental science Forecasting |
| Zdroj: | Journal of Applied Physiology. 89:2107-2116 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/jappl.2000.89.6.2107 |
| Popis: | A mixed-gas model for rats was developed to further explore the role of different gases in decompression and to provide a global model for possible future evaluation of its usefulness for human prediction. A Hill-equation dose-response model was fitted to over 5,000 rat dives by using the technique of maximum likelihood. These dives used various mixtures of He, N2, Ar, and O2 and had times at depth up to 2 h and varied decompression profiles. Results supported past findings, including 1) differences among the gases in decompression risk (He < N2 < Ar) and exchange rate (He > Ar ≈ N2), 2) significant decompression risk of O2, and 3) increased risk of decompression sickness with heavier animals. New findings included asymmetrical gas exchange with gas washout often unexpectedly faster than uptake. Model success was demonstrated by the relatively small errors (and their random scatter) between model predictions and actual incidences. This mixed-gas model for prediction of decompression sickness in rats is the first such model for any animal species that covers such a broad range of gas mixtures and dive profiles. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|