Degradation Kinetics of Atorvastatin under Stress Conditions and Chemical Analysis by HPLC
| Autor: | Valdenir José Belinelo, Marcelo Antonio de Oliveira, Romanélia Spessemille Valotto, Maria Irene Yoshida |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Drug
Time Factors Degradation kinetics Ultraviolet Rays media_common.quotation_subject Atorvastatin Pharmaceutical Science atorvastatin intrinsic stability degradation kinetics Pharmacology High-performance liquid chromatography Article Analytical Chemistry lcsh:QD241-441 chemistry.chemical_compound Reaction rate constant Drug Stability lcsh:Organic chemistry Drug Discovery medicine Sodium Hydroxide Pyrroles Physical and Theoretical Chemistry Chromatography High Pressure Liquid media_common Chromatography Chemistry Cholesterol Hydrolysis Organic Chemistry Temperature Reproducibility of Results Hydrogen-Ion Concentration Kinetics Polymorphism (materials science) Heptanoic Acids Chemistry (miscellaneous) Molecular Medicine Spectrophotometry Ultraviolet Hydrochloric Acid Stress conditions Oxidation-Reduction medicine.drug |
| Zdroj: | Molecules; Volume 18; Issue 2; Pages: 1447-1456 Molecules, Vol 18, Iss 2, Pp 1447-1456 (2013) Molecules |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules18021447 |
| Popis: | Atorvastatin is an antilipemic drug belonging to the statins class, whose reference drug is Pfizer's Lipitor®. It is used to reduce the levels of lipoproteins rich in cholesterol and reduce the risk of coronary artery disease. It is well-known that calcium atorvastatin (ATV), C₆₆H₆₈CaF₂N₄O₁₀•3H₂O, presents polymorphism. The drug in question is commonly sought after by pharmaceutical industries that produce generic drugs, due to the fact that the drug has a high value price, it is consumed globally, and its patent expired in late 2010. Many questions concerning this drug's pharmaceutical scope demonstrate its importance regarding stability studies and the identification of degradation products of drugs and pharmaceutical formulations. ATV has been found to degrade under acid and basic conditions, including a first order kinetic degradation under acid conditions, as compared to a zero order kinetic degradation under basic conditions, which tends to be less stable when studied within acid mediums. The rate constant (k) for degradation in acid medium was 1.88 × 10⁻² s⁻¹ (first order), while for basic medium k = 2.35 × 10⁻⁴ mol L⁻¹ s⁻¹ (zero order), demonstrating a lower stability of the drug within acid mediums. |
| Databáze: | OpenAIRE |
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