Magnetic Resonance Imaging Evaluation in Neoadjuvant Therapy of Locally Advanced Rectal Cancer: A Systematic Review
| Autor: | Roberta Fusco, Mario Sansone, Vincenza Granata, Antonella Petrillo, Salvatore Filice, Mario Petrillo, Orlando Catalano |
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| Přispěvatelé: | Fusco, Roberta, Petrillo, Mario, Granata, Vincenza, Filice, Salvatore, Sansone, Mario, Catalano, Orlando, Petrillo, Antonella |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Colorectal cancer medicine.medical_treatment R895-920 Review Surgical planning 030218 nuclear medicine & medical imaging 03 medical and health sciences Medical physics. Medical radiology. Nuclear medicine 0302 clinical medicine locally advanced rectal cancer False positive paradox Medicine magnetic resonance imaging Radiology Nuclear Medicine and imaging neoadjuvant therapy Neoadjuvant therapy evaluation medicine.diagnostic_test Receiver operating characteristic business.industry Magnetic resonance imaging medicine.disease Oncology Positron emission tomography 030220 oncology & carcinogenesis Radiology business Diffusion MRI |
| Zdroj: | Radiology and Oncology Radiology and Oncology, Vol 51, Iss 3, Pp 252-262 (2017) |
| ISSN: | 1581-3207 1318-2099 |
| Popis: | Background The aim of the study was to present an update concerning several imaging modalities in diagnosis, staging and pre-surgery treatment response assessment in locally advanced rectal cancer (LARC). Modalities include: traditional morphological magnetic resonance imaging (MRI), functional MRI such as dynamic contrast enhanced MRI (DCE-MRI) and diffusion weighted imaging (DWI). A systematic review about the diagnostic accuracy in neoadjuvant therapy response assessment of MRI, DCE-MRI, DWI and Positron Emission Tomography/Computed Tomography (PET/CT) has been also reported. Methods Several electronic databases were searched including PubMed, Scopus, Web of Science, and Google Scholar. All the studies included in this review reported findings about therapy response assessment in LARC by means of MRI, DCE-MRI, DWI and PET/CT with details about diagnostic accuracy, true and false negatives, true and false positives. Forest plot and receiver operating characteristic (ROC) curves analysis were performed. Risk of bias and the applicability at study level were calculated. Results Twenty-five papers were identified. ROC curves analysis demonstrated that multimodal imaging integrating morphological and functional MRI features had the best accuracy both in term of sensitivity and specificity to evaluate preoperative therapy response in LARC. DCE-MRI following to PET/CT showed high diagnostic accuracy and their results are also more reliable than conventional MRI and DWI alone. Conclusions Morphological MRI is the modality of choice for rectal cancer staging permitting a correct assessment of the disease extent, of the lymph node involvement, of the mesorectal fascia and of the sphincter complex for surgical planning. Multimodal imaging and functional DCE-MRI may also help in the assessment of treatment response allowing to guide the surgeon versus conservative strategies and/or tailored approach such as “wait and see” policy. |
| Databáze: | OpenAIRE |
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