Outbreak of hepatitis A in a post-vaccination era: High rate of co-infection with sexually transmitted diseases
| Autor: | Diego Arufe, Maria Del Valle Aubone, L. Gaite, Angel Oyervide, Martín Barrabino, Sebastián Marciano, Laura Garrido, Leila Haddad, Manuel Mendizabal, Ana Alicia Martinez, Adrián Gadano, Lucia de Labra, Natalia Ratusnu, Margarita Anders, Andrés Ruf, Lucrecia Rovey, Hugo Fainboim, Damián Conte, Hugo Tanno, Melisa Dirchwolf |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Sexually transmitted disease Pediatrics medicine.medical_specialty Argentina Sexually Transmitted Diseases Specialties of internal medicine Disease Outbreaks Men who have sex with men Young Adult 03 medical and health sciences 0302 clinical medicine Risk Factors Epidemiology medicine Humans Homosexuality Male Young adult Men who have sex with Men Hepatitis A Vaccines Hepatology Coinfection Transmission (medicine) business.industry Incidence (epidemiology) Hepatitis A Outbreak General Medicine Middle Aged medicine.disease Cross-Sectional Studies RC581-951 030220 oncology & carcinogenesis Female 030211 gastroenterology & hepatology Syphilis business |
| Zdroj: | Annals of Hepatology, Vol 19, Iss 6, Pp 641-644 (2020) |
| ISSN: | 1665-2681 |
| Popis: | Introduction and objectives After hepatitis A (HAV) mandatory immunization in 2005 in Argentina, the incidence of HAV declined drastically. However, several new autochthonous cases of HAV have been reported since 2017. We aimed to evaluate the clinical and epidemiological characteristics and possible transmission routes of affected patients. Patients or Materials and methods We performed a cross-sectional study of patients residing in Argentina with acute hepatitis A between 30.06.2017 and 31.12.2018. Results 66 cases of HAV were registered. Fifty-six patients (86%) were males, with a mean age of 34 ± 12 years old. The most likely routes of transmission were sexual intercourse of men with men, reported by 31 patients. Additionally, 23% and 26% of patients tested positive for HIV and syphilis, respectively. In total, 35% of patients required hospitalization. When assessing outcomes, 79% had a mild presentation and 21% had a severe/fulminant presentation: one patient underwent liver transplantation, and one patient died. Conclusions Our study describes that during the study period, HAV infection affected predominantly young adults, particularly men who have sex with men. An elevated proportion of them was diagnosed with a concomitant sexually transmitted disease, and several patients had a severe presentation of the disease. |
| Databáze: | OpenAIRE |
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