Regulation of long non-coding RNAs and genome dynamics by the RNA surveillance machinery

Autor: Lekha Nair, Uttiya Basu, Hachung Chung
Rok vydání: 2020
Předmět:
Zdroj: Nature Reviews Molecular Cell Biology. 21:123-136
ISSN: 1471-0080
1471-0072
DOI: 10.1038/s41580-019-0209-0
Popis: Much of the mammalian genome is transcribed, generating long non-coding RNAs (lncRNAs) that can undergo post-transcriptional surveillance whereby only a subset of the non-coding transcripts is allowed to attain sufficient stability to persist in the cellular milieu and control various cellular functions. Paralleling protein turnover by the proteasome complex, lncRNAs are also likely to exist in a dynamic equilibrium that is maintained through constant monitoring by the RNA surveillance machinery. In this Review, we describe the RNA surveillance factors and discuss the vital role of lncRNA surveillance in orchestrating various biological processes, including the protection of genome integrity, maintenance of pluripotency of embryonic stem cells, antibody–gene diversification, coordination of immune cell activation and regulation of heterochromatin formation. We also discuss examples of human diseases and developmental defects associated with the failure of RNA surveillance mechanisms, further highlighting the importance of lncRNA surveillance in maintaining cell and organism functions and health. Mammalian genomes generate long non-coding RNAs, which are degraded by the RNA surveillance machinery. This regulated degradation is vital for various processes, including for genome integrity, stem cell pluripotency and immune cell activation. Consequently, defects in RNA surveillance cause human diseases and developmental disorders.
Databáze: OpenAIRE
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