Oncogene and tumor suppressor gene expression changes in the peripheral blood leukocytes of patients with colorectal cancer
| Autor: | Örs Péter Horváth, Edit Nádasi, Annamária Zólyomi, Laszlo Lukacs, Istvan Ember, Attila Kvarda, Andras Csejtey, Zsolt Csontos, Kassai M, László Illényi, Dezso Kelemen |
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| Rok vydání: | 2008 |
| Předmět: |
Oncology
Male Cancer Research medicine.medical_specialty Tumor suppressor gene Colorectal cancer Population Mouse model of colorectal and intestinal cancer Adenocarcinoma 030218 nuclear medicine & medical imaging Proto-Oncogene Proteins c-myc 03 medical and health sciences 0302 clinical medicine Internal medicine Gene expression medicine Biomarkers Tumor Leukocytes Humans education Gene education.field_of_study Oncogene business.industry Cancer General Medicine Middle Aged medicine.disease Gene Expression Regulation Neoplastic Genes ras 030220 oncology & carcinogenesis Case-Control Studies Colonic Neoplasms Female Tumor Suppressor Protein p53 business |
| Zdroj: | Tumori. 94(1) |
| ISSN: | 0300-8916 |
| Popis: | Aims and background The mortality of colorectal cancer continues to stagnate despite the development of new therapeutic approaches. Therefore, identifying high-risk population groups could contribute to the prevention of a considerable part of deaths caused by colorectal tumors. Methods Fifty patients with colon cancer and 50 patients with other, nonmalignant diseases were selected for the study. Expression of the c-myc, Ha-ras and p53 genes was determined in the peripheral leukocytes of the participants. Results Marked elevations of the expression of all three investigated genes were seen in the colon cancer patients when compared to the controls. Conclusions Our investigations showed that increases in the expression of c-myc, Ha-ras and p53 genes can be demonstrated in the peripheral leukocytes of colon cancer patients. By applying our method to clinical investigations, individuals with a high risk of having developed colon cancer may be identified and early diagnosis may be established. |
| Databáze: | OpenAIRE |
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