Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging
| Autor: | Artūras Petronis, Daniel E. Groot, Juozas Gordevičius, Karolis Koncevičius, Akhil Nair, Miki Susic, Viviane Labrie, Gabriel Oh, Edward Saehong Oh, Richie Jeremian, Matthew Carlucci, Aiping Zhang, Martin R. Ralph, Peixin Jia, Tenjin C. Shrestha, Sasha Ebrahimi |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Proteomics Aging Science General Physics and Astronomy Biology General Biochemistry Genetics and Molecular Biology Article Epigenesis Genetic Transcriptome 03 medical and health sciences chemistry.chemical_compound Cytosine Mice Animals Circadian rhythm Epigenetics lcsh:Science Epigenesis 5-Hydroxymethylcytosine Multidisciplinary Genetic Variation General Chemistry DNA Methylation Cell biology Circadian Rhythm 5-Methylcytosine 030104 developmental biology chemistry DNA methylation lcsh:Q gene-expression c-Myc disease clock mammals protein 5-hydroxymethylcytosine 5-methylcytosine transcription |
| Zdroj: | Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018) Nature communications, London : Nature Publishing Group, 2018, Vol. 9, art. no. 644, p. 1-11 Nature Communications |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-018-03073-7 |
| Popis: | Circadian rhythmicity governs a remarkable array of fundamental biological functions and is mediated by cyclical transcriptomic and proteomic activities. Epigenetic factors are also involved in this circadian machinery; however, despite extensive efforts, detection and characterization of circadian cytosine modifications at the nucleotide level have remained elusive. In this study, we report that a large proportion of epigenetically variable cytosines show a circadian pattern in their modification status in mice. Importantly, the cytosines with circadian epigenetic oscillations significantly overlap with the cytosines exhibiting age-related changes in their modification status. Our findings suggest that evolutionary advantageous processes such as circadian rhythmicity can also contribute to an organism’s deterioration. While epigenetic factors have been implicated in the circadian rhythm, the detection of circadian cytosine modifications has remained elusive. Here the authors identify a large number of epigenetically variable cytosines that show circadian oscillations in their modification status in mice. |
| Databáze: | OpenAIRE |
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