Mechanisms of vortices termination in the cardiac muscle
| Autor: | Niels F. Otani, Valentin Krinsky, S. Han, Vadim N. Biktashev, Stefan Luther, T. K. Shajahan, Sebastian Berg, Daniel Hornung, Tariq Baig |
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| Rok vydání: | 2017 |
| Předmět: |
implantable defibrillator
Defibrillation weakly pinned vortices medicine.medical_treatment Quantitative Biology::Tissues and Organs Physics::Medical Physics Implantable defibrillator 01 natural sciences 010305 fluids & plasmas Engineering Electric field Condensed Matter::Superconductivity 0103 physical sciences medicine lcsh:Science 010306 general physics Tissues and Organs (q-bio.TO) Simulation Fibrillation Physics Multidisciplinary Cardiac muscle Direct observation Quantitative Biology - Tissues and Organs nonlinear waves Mechanics medicine.disease Vortex medicine.anatomical_structure FOS: Biological sciences Ventricular fibrillation lcsh:Q medicine.symptom cardiac fibrillation Research Article |
| Zdroj: | Royal Society Open Science Royal Society Open Science, Vol 4, Iss 3 (2017) |
| ISSN: | 2054-5703 |
| Popis: | We propose a solution to a long standing problem: how to terminate multiple vortices in the heart, when the locations of their cores and their critical time windows are unknown. We scan the phases of all pinned vortices in parallel with electric field pulses (E-pulses). We specify a condition on pacing parameters that guarantees termination of one vortex. For more than one vortex with significantly different frequencies, the success of scanning depends on chance, and all vortices are terminated with a success rate of less than one. We found that a similar mechanism terminates also a free (not pinned) vortex. A series of about 500 experiments with termination of ventricular fibrillation by E-pulses in pig isolated hearts is evidence that pinned vortices, hidden from direct observation, are significant in fibrillation. These results form a physical basis needed for the creation of new effective low energy defibrillation methods based on the termination of vortices underlying fibrillation. Comment: 7 pages, 6 figures, as accepted to Royal Society Open Science |
| Databáze: | OpenAIRE |
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