Identification of hydroxylated metabolites in 2,2′,4,4′-tetrabromodiphenyl ether exposed rats
| Autor: | Maria Athanasiadou, Göran Marsh, Anna Sandholm, Ioannis Athanassiadis |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Marine sponges
Environmental Engineering Health Toxicology and Mutagenesis Metabolite Polybrominated Biphenyls Ether Hydroxylation Gas Chromatography-Mass Spectrometry Feces chemistry.chemical_compound Halogenated Diphenyl Ethers Animals Environmental Chemistry Organic chemistry Phenyl Ethers 2 2 4 4 tetrabromodiphenyl ether Public Health Environmental and Occupational Health General Medicine General Chemistry Pollution Hydrocarbons Brominated Rats chemistry Gas chromatography Hydroxylated Polybrominated Diphenyl Ether |
| Zdroj: | Chemosphere. 63:690-697 |
| ISSN: | 0045-6535 |
| Popis: | Faeces from day 1-5 of orally administered 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) in rat have been analysed for hydroxylated metabolites. Six hydroxylated tetrabrominated diphenyl ethers, as well as three hydroxylated tribrominated diphenyl ethers found, were structurally identified. They were 2'-hydroxy-2,4,4'-tribromodiphenyl ether, 3'-hydroxy-2,4,4'-tribromodiphenyl ether, 4'-hydroxy-2,2',4-tribromodiphenyl ether, 6-hydroxy-2,2',4,4'-tetrabromodiphenyl ether, 2'-hydroxy-2,3',4,4'-tetrabromodiphenyl ether, 3-hydroxy-2,2',4,4'-tetrabromodiphenyl ether, 5-hydroxy-2,2',4,4'-tetrabromodiphenyl ether, 4'-hydroxy-2,2',4,5'-tetrabromodiphenyl ether and 4-hydroxy-2,2',3,4'-tetrabromodiphenyl ether. The analysis was performed using gas chromatography-mass spectrometry (GC-MS). The identification of the hydroxylated polybrominated diphenyl ether (OH-PBDE) metabolites in the rat faeces was supported by similar relative retention times (RRTs) versus 2,2',3,4,4',5-hexabromodiphenyl ether (BDE-138) on two columns of different polarities compared to the authentic references. The identification of the OH-PBDE metabolites was also supported by full scan electron ionisation mass spectra. Two of the identified OH-PBDE metabolites have identical structures as natural products, which previously have been isolated from marine sponges and an ascidian. |
| Databáze: | OpenAIRE |
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