The influence of ionotropic and metabotropic glutamate receptor ligands on anxiety-like effect of amphetamine withdrawal in rats
| Autor: | Dorota Kołtunowska, Ewa Gibula-Bruzda, Jolanta Kotlinska |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
Pyridines Taurine Acamprosate Anxiety Pharmacology Ligands Receptors Ionotropic Glutamate Receptors Metabotropic Glutamate Bridged Bicyclo Compounds Memantine Excitatory Amino Acid Agonists medicine Animals Amphetamine Biological Psychiatry Dose-Response Relationship Drug Metabotropic glutamate receptor 5 Rats Substance Withdrawal Syndrome Thiazoles MTEP Metabotropic receptor Metabotropic glutamate receptor NMDA receptor Metabotropic glutamate receptor 2 Psychology Excitatory Amino Acid Antagonists medicine.drug |
| Zdroj: | Progress in Neuro-Psychopharmacology and Biological Psychiatry. 45:242-249 |
| ISSN: | 0278-5846 |
| DOI: | 10.1016/j.pnpbp.2013.04.013 |
| Popis: | Chronic amphetamine use results in anxiety-like states after drug cessation. The aim of the study was to determine a role of ionotropic and metabotropic glutamate receptor ligands in amphetamine-evoked withdrawal anxiety in the elevated plus-maze test in rats. In our study memantine (8 and 12 mg/kg), a noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist did not reduce amphetamine withdrawal anxiety. Acamprosate (NMDA and metabotropic glutamate 5 receptor (mGluR5) antagonist) at the dose 200 and 400mg/kg showed anxiolytic-like effect, thus increasing the percent of time spent in open arms and a number of open arm entries. mGluR5 selective antagonist, MTEP (3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine hydrochloride) and mGluR2/3 agonist, LY354740 (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid), caused effects similar to acamprosate at doses 1.25-5mg/kg and 2.5-5mg/kg, respectively. None of the glutamate ligands influenced locomotor activity of rats when given to the saline-treated group. Taking into account the positive correlation between amphetamine withdrawal-induced anxiety and relapse to amphetamine taking, our results suggest that modulation of mGluRs may prevent relapse to amphetamine and might pose a new direction in amphetamine abuse therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect