Clinical Significance of KL-6, a Marker of Interstitial Pneumonia, in Cases of HCV-associated Chronic Liver Disease
| Autor: | Takeshi Arima, Hajime Kuwayama, Rie Ohyama, Satoshi Kanouzawa, Hiroshi Takada, Kazutomo Suzuki, Shigeki Oka, Mamoru Iimuro, Yoshinori Kitazumi |
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| Rok vydání: | 2003 |
| Předmět: |
Liver Cirrhosis
Male medicine.medical_specialty Pathology Cirrhosis Autoimmune hepatitis Serum Hyaluronic Acid Chronic liver disease Gastroenterology Antigens Neoplasm Predictive Value of Tests Internal medicine Internal Medicine medicine Humans Clinical significance Antigens Hyaluronic Acid Aged Glycoproteins business.industry Liver Diseases Mucin-1 Respiratory disease Mucins General Medicine Hepatitis C Hepatitis C Chronic Middle Aged medicine.disease Hepatocellular carcinoma Chronic Disease Female Lung Diseases Interstitial business Biomarkers |
| Zdroj: | Internal Medicine. 42:650-654 |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.42.650 |
| Popis: | Objective Various antiviral therapies, including interferon therapy, are being conducted to treat chronic hepatitis C and suppress the onset of hepatocellular carcinoma. However, interstitial pneumonia is beginning to be recognized as one of the adverse reactions of this therapy, and is one of the complications associated with chronic hepatitis. Therefore, we measured the level of KL-6, an interstitial pneumonia marker, in patients with HCV-associated chronic disease, and then determined the possibility of utilizing serum KL-6 as a predictive factor for interstitial pneumonia and the clinical significance of KL-6 in HCV-associated chronic disease. Subjects and Methods The subjects were 308 patients who were diagnosed with chronic liver disease through biochemical blood tests and abdominal diagnostic imaging. All patients tested positive for either the HCV antibody or HCV-RNA, and those who were suspected of having autoimmune hepatitis were excluded. One hundred eighty-five patients had chronic hepatitis (average age: 56±14 years), while 123 patients had liver cirrhosis (average age: 64±9 years). The purpose of the present study was explained to every subject, and informed consent was obtained. Results The mean KL-6 level for chronic hepatitis patients without interstitial pneumonia was 283.5±131.4 U/ml, while that for cirrhotic patients without interstitial pneumonia was significantly higher, at 377.6±212.1 U/ml (p |
| Databáze: | OpenAIRE |
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