GnRH agonist trigger and a freeze-all strategy to prevent ovarian hyperstimulation syndrome: a retrospective study of OHSS risk and pregnancy rates
| Autor: | Juliette Koch, Paul Atkinson, William J. Ledger |
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| Rok vydání: | 2014 |
| Předmět: |
Agonist
Adult medicine.medical_specialty Pregnancy Rate medicine.drug_class medicine.medical_treatment Ovarian hyperstimulation syndrome Oocyte Retrieval Controlled ovarian hyperstimulation Fertilization in Vitro Gonadotropin-Releasing Hormone Nafarelin Ovarian Hyperstimulation Syndrome Ovulation Induction Pregnancy medicine Humans Retrospective Studies Gynecology Cryopreservation In vitro fertilisation business.industry Obstetrics Obstetrics and Gynecology Retrospective cohort study General Medicine Fertility Agents Female medicine.disease Embryo Mammalian Embryo transfer Pregnancy rate Oocytes Female Follicle Stimulating Hormone Leuprolide business |
| Zdroj: | The AustralianNew Zealand journal of obstetricsgynaecology. 54(6) |
| ISSN: | 1479-828X |
| Popis: | Aims To analyse the data from all controlled ovarian hyperstimulation antagonist cycles that used an agonist trigger and a freeze-all strategy to quantify the risk of ovarian hyperstimulation syndrome (OHSS) and subsequent pregnancy rates. Materials and Methods A retrospective study of all women attending fertility clinics at IVF Australia, Sydney, undergoing controlled ovarian hyperstimulation (COH) using an antagonist protocol that had a subsequent gonadotropin-releasing hormone (GnRH) agonist trigger and freezing of all oocytes or embryos. The primary outcome measure was to determine the rate of OHSS. The secondary outcome measure was the clinical pregnancy rate. Results We collected data for 123 women. 25.2% were undergoing oocyte freezing and 74.8% underwent embryo freezing. There were no cases of OHSS, either early or late onset. The pregnancy rate was 31.7% after the first frozen cycle transfer with a cumulative pregnancy rate of 50% after two frozen embryo transfers. Conclusion Our results support the hypothesis that a GnRH agonist trigger and a freeze-all approach prevents OHSS with a good pregnancy rate. |
| Databáze: | OpenAIRE |
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