FLOW CYTOMETRIC DNA ANALYSIS IN PREDICTION OF INTRAVESICAL RECURRENCE FROM HUMAN BLADDER-CANCER

Autor:	S Cucciarre, A Russo, M Pavonemacaluso, Aldo Vecchione, R Campanella, I Carreca, G Dardanoni, Bazan
Rok vydání:	1994
Předmět:	Cancer Research medicine.medical_specialty Multivariate analysis Human bladder Urology Cancer Biology medicine.disease Resection Oncology Immunology Carcinoma medicine Statistical analysis Stage (cooking) Frozen tissue
Zdroj:	International Journal of Oncology.
ISSN:	1791-2423 1019-6439
DOI:	10.3892/ijo.5.3.633
Popis:	A series of 128 patients undergoing diagnostic and/or therapeutic transurethral resection for primary urothelial bladder carcinoma was prospectively studied in order to evaluate the relative importance of DNA-ploidy and S-phase fraction (SPF) by flow cytometry and of several clinicopathological features in predicting disease-free survival. Only frozen tissue was used. The mean follow-up was 22 months (range: 3-61 months). DNA-aneuploidy was present in 64% of the cases (82/128), while multiclonality was found in 29% of the DNA-aneuploid cases (24/82). In the univariate statistical analysis, high stage, DNA-aneuploidy (mono- and multiclonal patterns) and high SPF value (>11.6%) proved to be significantly related to the risk of intravesical recurrence, while a significant trend was present for histological grade. In the multivariate analysis only high SPF value (>11.6%) and DNA-aneuploidy were independently related to risk of relapse (RR of 2.39 and 2.40 respectively).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62621a192a17a8041df02ddb9a36fe88 https://doi.org/10.3892/ijo.5.3.633 Zobrazit plný text záznamu