Nanoscale hepatoprotective herbal decoction attenuates hepatic stellate cell activity and chloroform-induced liver damage in mice
| Autor: | Miffy Yang, Walter H. Chang, Justin Jin-Ching Chen, Sherry Huang, Shu Jen Chang |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Liver Cirrhosis
Biophysics Pharmaceutical Science Bioengineering Decoction Traditional Chinese medicine Pharmacology Body weight Protective Agents Biomaterials chemistry.chemical_compound Mice Drug Delivery Systems International Journal of Nanomedicine Drug Discovery Hepatic Stellate Cells Medicine Animals Nanotechnology Particle Size Original Research liver fibrosis Liver injury Mice Inbred ICR Chloroform Tissue Inhibitor of Metalloproteinase-1 business.industry Histocytochemistry nanoparticle Organic Chemistry Body Weight Chinese herb medicine General Medicine Organ Size medicine.disease Rhizome Bioavailability San-Huang-Xie-Xin-Tang chemistry Liver Hepatic stellate cell Matrix Metalloproteinase 2 Nanoparticles Female Chemical and Drug Induced Liver Injury business Drugs Chinese Herbal |
| Zdroj: | International Journal of Nanomedicine |
| ISSN: | 1178-2013 |
| Popis: | Sherry Huang1, Shu-Jen Chang2, Miffy Yang3, Justin Jin-Ching Chen3, Walter H Chang41Department of Biomedical Engineering, Chung Yuan Christian University, Chungli, Taiwan; 2School of Pharmacy, China Medical University, Taichung, Taiwan; 3Center for Nano Bioengineering, 4Department of Biomedical Engineering, Chung Yuan Christian University, Chungli, TaiwanBackground: San-Huang-Xie-Xin-Tang (SHXXT) decoction, a traditional Chinese medicine containing Rhei rhizome, Coptidis rhizome, and Scutellariae radix, is widely used in hepatoprotective therapy. However, preparation of the decoction requires addition of boiling water that causes loss of numerous effective components.Methods: To improve the bioavailability of the decoction, nanoscale SHXXT was developed. Chloroform-induced liver injury and hepatic stellate cell activity in mice were used to demonstrate the hepatoprotective characteristics of nanoscale SHXXT decoction.Results: Liver/body weight ratio and serum aspartate and alanine aminotranferase levels were recovered by the nanoscale SHXXT. TIMP-1 gene expression was inhibited and MMP-2 gene expression was accelerated in activated hepatic stellate cells.Conclusion: Nanoscale SHXXT decoction prepared in room temperature water could have preserved hepatoprotective ability. The results of this study indicate that nanoscale SHXXT could be extracted easily. The simple preparation of this herbal decoction is more convenient and energy-efficient.Keywords: Chinese herb medicine, San-Huang-Xie-Xin-Tang, nanoparticle, liver fibrosis |
| Databáze: | OpenAIRE |
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