Lower Limb Metaphyseal Bone Is Lost in Men with Coeliac Disease and Does Not Relate to Parathyroid Status
| Autor: | S.F. Evans, Michael W. J. Davie, CA Sharp |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Bone density Article Subject Endocrinology Diabetes and Metabolism Urinary system Parathyroid hormone lcsh:Medicine 030209 endocrinology & metabolism 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Internal medicine medicine Femoral neck Bone mineral Creatinine business.industry lcsh:R musculoskeletal system Urinary calcium medicine.anatomical_structure chemistry Alkaline phosphatase 030211 gastroenterology & hepatology business Research Article |
| Zdroj: | Journal of Osteoporosis Journal of Osteoporosis, Vol 2016 (2016) |
| ISSN: | 2090-8059 |
| DOI: | 10.1155/2016/4131794 |
| Popis: | Aims. To investigate regional lower limb bone density and associations with weight, PTH, and bone breakdown in coeliac men.Methods. From whole body DXA scans bone mineral density (BMD) was measured in 28 coeliac men, in the lower limb (subdivided into 6 regions, 3 being metaphyseal (mainly trabecular) and 2 diaphyseal (mainly cortical)). BMD at femoral neck (FN) and lumbar spine L2–4, body weight, height, serum calcium, alkaline phosphatase, parathyroid hormone (PTH), and urinary calcium and NTx/Cr, a measure of bone breakdown, were also measured. Age matched healthy men provided values for BMD calculation ofzandTscores and for biochemical measurements.Results. Low BMDzscores were found at metaphyseal regions in the leg (p<0.001) and in the FN (p<0.05). The distal metaphyseal region BMD in the leg was lower than spine or FN (p<0.05). PTH, urinary calcium/creatinine, and urinary NTx/Cr were similar to controls. Both metaphyseal and diaphyseal BMDzscores were associated with body weight (p<0.02), but not with either PTH or urinary NTx/Cr.Conclusions. Low BMD lower limb regions comprising mostly trabecular bone occur early in CD and in the absence of elevated PTH or increased bone resorption. Low BMD is associated with low body weight. |
| Databáze: | OpenAIRE |
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