Mechanisms of Reciprocal Regulation of Gonadotropin-Releasing Hormone (GnRH)-Producing and Immune Systems: The Role of GnRH, Cytokines and Their Receptors in Early Ontogenesis in Normal and Pathological Conditions
| Autor: | Marina Izvolskaia, V. S. Sharova, L. A. Zakharova |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
endocrine system GnRH receptors Ontogeny Thymus Gland Review Gonadotropin-releasing hormone Biology Catalysis Epigenesis Genetic Proinflammatory cytokine Gonadotropin-Releasing Hormone early ontogenesis HPG and immune systems lcsh:Chemistry Inorganic Chemistry Mice Immune system Animals Humans Epigenetics Physical and Theoretical Chemistry Receptor lcsh:QH301-705.5 Molecular Biology Pathological Spectroscopy Inflammation Neurons Neurotransmitter Agents thymic development Organic Chemistry perinatal programming General Medicine GnRH neuron migration Rats Computer Science Applications Gene Expression Regulation lcsh:Biology (General) lcsh:QD1-999 Immune System Cytokines Female signal molecules Cell Adhesion Molecules Neuroscience Signal Transduction Transcription Factors Hormone |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 114, p 114 (2021) International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| Popis: | Different aspects of the reciprocal regulatory influence on the development of gonadotropin-releasing hormone (GnRH)-producing- and immune systems in the perinatal ontogenesis and their functioning in adults in normal and pathological conditions are discussed. The influence of GnRH on the development of the immune system, on the one hand, and the influence of proinflammatory cytokines on the development of the hypothalamic-pituitary-gonadal system, on the other hand, and their functioning in adult offspring are analyzed. We have focused on the effects of GnRH on the formation and functional activity of the thymus, as the central organ of the immune system, in the perinatal period. The main mechanisms of reciprocal regulation of these systems are discussed. The reproductive health of an individual is programmed by the establishment and development of physiological systems during critical periods. Regulatory epigenetic mechanisms of development are not strictly genetically controlled. These processes are characterized by a high sensitivity to various regulatory factors, which provides possible corrections for disorders. |
| Databáze: | OpenAIRE |
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