Scintigraphic potentials of J001X acylated poly-galactoside for imaging inflammatory lesions in pigs
| Autor: | A. Le Pape, H. Binz, F. Perin, D. Hoffschir, J.-C. Pittet, G. Normier |
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| Rok vydání: | 1993 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty Swine Gallium Radioisotopes Inflammation Disease Scintigraphy Sensitivity and Specificity chemistry.chemical_compound medicine Animals Macrophage Radiology Nuclear Medicine and imaging Radionuclide Imaging Myositis medicine.diagnostic_test business.industry Macrophages Muscles Acetylation Fibrosis Galactoside Disease Models Animal Technetium Compounds chemistry Molecular Medicine Female Glycolipids medicine.symptom business |
| Zdroj: | Nuclear Medicine and Biology. 20:963-971 |
| ISSN: | 0969-8051 |
| DOI: | 10.1016/0969-8051(93)90097-e |
| Popis: | Although several approaches already exist for the imaging of inflammatory foci, new specific strategies providing functional data on the lesions are required to determine the extent of the disease and also to assess anti-inflammatory treatment. In our study, we investigated the scintigraphic potential of 99mTc-J001X, an agent developed for the targeting of macrophages. Due to its well documented and progressive evolution of lesions, a model of radiation-induced inflammation in pigs was chosen. Our results demonstrated the ability of J001X to provide images of inflammatory foci with a high contrast. The contribution of some specific and non-specific parameters possibly involved in the scintigraphic behavior of J001X is discussed. |
| Databáze: | OpenAIRE |
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