Doxorubicin-induced oxidative stress in rats is efficiently counteracted by dietary anthocyanin differently enriched strawberry (Fragaria × ananassa Duch.)
| Autor: | Celestino Santos-Buelga, Adrian Gonzalez-Alonso, Francesca Giampieri, José M. Alvarez-Suarez, Maria del Carmen Ramirez-Tortosa, José L. Quiles, Sergio Granados-Principal, Jacopo Diamanti, Maurizio Battino, Ana M. Gonzàles-Paramàs, Bruno Mezzetti |
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| Rok vydání: | 2014 |
| Předmět: |
Mitochondrial ROS
Male Antioxidant Normal diet medicine.medical_treatment Pharmacology Biology medicine.disease_cause Fragaria Anthocyanins Lipid oxidation polycyclic compounds medicine Animals Humans Rats Wistar Vitamin C General Chemistry Mitochondria Rats Oxidative Stress Biochemistry Liver Doxorubicin Toxicity Chemical and Drug Induced Liver Injury General Agricultural and Biological Sciences Oxidative stress DNA Damage |
| Zdroj: | Journal of agricultural and food chemistry. 62(18) |
| ISSN: | 1520-5118 |
| Popis: | This study investigated the effects of two different strawberry cultivars, Adria and Sveva, against doxorubicin (DOX)-induced toxicity in rats. A controlled dietary intervention was conducted over 16 weeks with four groups: (i) normal diet; (ii) normal diet + DOX injection; (iii) Adria supplementation + DOX injection; and (iv) Sveva supplementation + DOX injection. Sveva presented higher total antioxidant capacity value and phenol and and vitamin C levels than Adria, which in turn presented higher anthocyanin contents. DOX drastically increased lymphocyte DNA damage, liver biomarkers of protein and lipid oxidation, and mitochondrial ROS content and markedly decreased plasma retinol level, liver antioxidant enzymes, and mitochondrial functionality. After 2 months of strawberry supplementation, rats presented a significant reduction of DNA damage and ROS concentration and a significant improvement of oxidative stress biomarkers, antioxidant enzyme activities, and mitochondrial performance. These results suggest that strawberry supplementation can counteract DOX toxicity, confirming the potential health benefit of strawberry in vivo against oxidative stress. |
| Databáze: | OpenAIRE |
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