Unsuspected Lung Pathology in Autopsies of Children with Cancer
| Autor: | Mario H. Vargas, Elba E. Delgado-González, Enrique López-Aguilar, María del Carmen Rodríguez-Zepeda, Olivia Madrigal-Muñiz, Miguel Ángel Villasís-Keeverz, Alicia Rodríguez-Velasco, María E.Y. Furuya, Rocío Cárdenas-Navarrete, Carina Feria-Kaiser, Martha Sciandra-Rico |
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| Rok vydání: | 2017 |
| Předmět: |
Lung Diseases
Male medicine.medical_specialty Pediatrics Adolescent Hemorrhage Autopsy 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Neoplasms 030225 pediatrics Internal medicine Humans Medicine Child Pathological Hematology Lung business.industry Infant Newborn Infant Cancer General Medicine medicine.disease Pneumonia medicine.anatomical_structure Child Preschool Female Radiology Pulmonary hemorrhage business Medical literature |
| Zdroj: | Revista de investigaci�n Cl�nica. 69 |
| ISSN: | 0034-8376 |
| DOI: | 10.24875/ric.17002098 |
| Popis: | Background: Although pulmonary involvement is common in patients with cancer, its frequency and nature is seldom reported in the medical literature. Objective: To determine the frequency and type of lung pathological conditions revealed by autopsy in children with cancer. Methods: All reports from autopsies performed in children with cancer from 1989 to 2012 in a pediatric hospital were reviewed. Results: In the analyzed period, 118 autopsies (10.2% of all autopsies) corresponded to children who died with cancer; 76 had complete information and were included in the analysis. Children were seen in the Hematology (41 cases) or the Oncology (35 cases) services. Their median age at decease was 7 years (range, 15 days to 16.1 years) and 46.1% were females. Main diagnoses were acute lymphoblastic (31 patients) or myeloblastic (10 patients) leukemias and tumors of the central nervous system (12 patients). A pathological respiratory condition was diagnosed antemortem in 31 (40.8%) patients, and at autopsy in 62 (81.6%) cases. Omitted diagnoses occurred in 58 (76.3%) children, being pneumonia (24 cases) and pulmonary hemorrhage (23 cases) the most frequent omissions. Nine patients had clinically unsuspected tumor infiltration or metastases. Conclusions: In these children with cancer, more than 80% of autopsies revealed some lung pathology, mainly of infectious or hemorrhagic nature. Thus, pulmonary involvement should be investigated in all children with cancer in a timely and intentional manner. (Rev Inves ClIn. 2017;69:28-32) |
| Databáze: | OpenAIRE |
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