Exploiting the nephrotoxic effects of venom from the sea anemone, phyllodiscus semoni, to create a hemolytic uremic syndrome model in the rat
| Autor: | Masashi Mizuno, Bryan Paul Morgan, Yasuhiko Ito |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
renal failure
food.ingredient sea anemone Pharmaceutical Science Phyllodiscus Venom Review Pharmacology Biology Sea anemone urologic and male genital diseases complex mixtures Nephrotoxicity Cnidarian Venoms food Drug Discovery medicine complement regulators Animals Humans complement marine envenomation Pharmacology Toxicology and Pharmaceutics (miscellaneous) Thrombotic Microangiopathies Acute kidney injury Anatomy Acute Kidney Injury medicine.disease biology.organism_classification R1 Hemolysis Rats Complement system Disease Models Animal Sea Anemones Hemolytic-Uremic Syndrome hemolytic uremic syndrome Coelenterata |
| Zdroj: | Marine Drugs |
| ISSN: | 1660-3397 |
| Popis: | In the natural world, there are many creatures with venoms that have interesting and varied activities. Although the sea anemone, a member of the phylum Coelenterata, has venom that it uses to capture and immobilise small fishes and shrimp and for protection from predators, most sea anemones are harmless to man. However, a few species are highly toxic; some have venoms containing neurotoxins, recently suggested as potential immune-modulators for therapeutic application in immune diseases. Phyllodiscus semoni is a highly toxic sea anemone; the venom has multiple effects, including lethality, hemolysis and renal injuries. We previously reported that venom extracted from Phyllodiscus semoni induced acute glomerular endothelial injuries in rats resembling hemolytic uremic syndrome (HUS), accompanied with complement dysregulation in glomeruli and suggested that the model might be useful for analyses of pathology and development of therapeutic approaches in HUS. In this mini-review, we describe in detail the venom-induced acute renal injuries in rat and summarize how the venom of Phyllodiscus semoni could have potential as a tool for analyses of complement activation and therapeutic interventions in HUS. |
| Databáze: | OpenAIRE |
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