Incidence of Hodgkin lymphoma in HIVpositive and HIVnegative patients at a tertiary hospital in South Africa 2005 2016 and comparison with other African countries
| Autor: | C Locketz, Ravnit Grewal, Fungai Musaigwa, A Abayomi, Nasheen Naidoo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty lcsh:Medicine 03 medical and health sciences 0302 clinical medicine Nodular sclerosis Internal medicine Biopsy Epidemiology medicine 030212 general & internal medicine Lymph node lcsh:R5-920 medicine.diagnostic_test business.industry Incidence (epidemiology) lcsh:R Cancer Retrospective cohort study General Medicine medicine.disease 030112 virology medicine.anatomical_structure Bone marrow business lcsh:Medicine (General) |
| Zdroj: | South African Medical Journal, Vol 108, Iss 7, Pp 653-567 (2018) SAMJ: South African Medical Journal, Volume: 108, Issue: 7, Pages: 563-567, Published: JUL 2018 |
| ISSN: | 0256-9574 2078-5135 |
| Popis: | Background. Hodgkin lymphoma (HL) is the most common non-AIDS-defining cancer in HIV-positive patients. Studies on South African (SA) populations have described the prevalence as 7 - 17% of all lymphomas, 8 - 27% of head and neck lymphomas, 9% of lymph node biopsies and 4% of HIV-related malignancies. Objectives. To describe the incidence of HL at our centre between 2005 and 2016 by year, gender, HIV status, histological subclassification and bone marrow involvement, and compare these findings with similar SA and African studies. Methods. This was a retrospective study of all incident HL cases diagnosed in the Department of Pathology, National Health Laboratory Service, Tygerberg Academic Hospital, Cape Town. Follow-up, relapsed and referral cases were excluded. A positive diagnosis of HL was confirmed by either lymph node or bone marrow biopsy and was based on morphological and immunohistochemical findings in accordance with the World Health Organization classification. Results. There were 303 incident cases of HL diagnosed. The incidence increased from 2005 to 2011, with a spike in cases in 2008 and a subsequent decline overall after 2011. The highest proportion of cases was in the 25 - 49-year-old age category (51.1%). There were 77 HIV-positive patients (25.4%), of whom 53 (68.8%) had CD4+ counts |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|