Confined compression of collagen hydrogels
| Autor: | Philip Riches, M. Helen Grant, Grahame Busby, Simon P. Mackay |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Compressive Strength
Biomedical Engineering Biophysics Aggregate modulus macromolecular substances Matrix (biology) complex mixtures Models Biological Collagen Type I Permeability Tissue engineering TA164 Elastic Modulus Animals Orthopedics and Sports Medicine Elastic modulus Tissue Scaffolds Chemistry Rehabilitation technology industry and agriculture Hydrogels Biomechanical Phenomena Rats Compressive strength Permeability (electromagnetism) Self-healing hydrogels Stress Mechanical Biomedical engineering Confined compression |
| Zdroj: | Journal of biomechanics. 46(4) |
| ISSN: | 1873-2380 0021-9290 |
| Popis: | Reconstituted collagen hydrogels are often used for in vitro studies of cell-matrix interaction and as scaffolds for tissue engineering. Understanding the mechanical and transport behaviours of collagen hydrogels is therefore extremely important, albeit difficult due to their very high water content (typically >99.5%). In the present study the mechanical behaviour of collagen hydrogels in confined compression was investigated using biphasic theory (J Biomechemical Engineering 102 (1980) 73), to ascertain whether the technique is sufficiently sensitive to determine differences in the characteristics of hydrogels of between 0.2% and 0.4% collagen. Peak stress, equilibrium stress, aggregate modulus and hydraulic permeability of the hydrogels exhibited sensitivity to collagen content, demonstrating that the technique is clearly able to discriminate between hydrogels with small differences in collagen content and may also be sensitive to factors that affect matrix remodelling. The results also offer additional insight into the deformation-dependent permeability of collagen hydrogels. This study suggests that confined compression, together with biphasic theory, is a suitable technique for assessing the mechanical properties of collagen hydrogels. |
| Databáze: | OpenAIRE |
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