Combining Medications to Enhance Depression Outcomes (CO-MED): Acute and Long-Term Outcomes of a Single-Blind Randomized Study
Autor: | Stephen R. Wisniewski, Diane Warden, Benji T. Kurian, Ian A. Cook, Mustafa M. Husain, Richard C. Shelton, James F. Luther, Andrew A. Nierenberg, Madhukar H. Trivedi, Jonathan W. Stewart, A. John Rush, Susan G. Kornstein, Ira M. Lesser, David W. Morris, Maurizio Fava |
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Rok vydání: | 2012 |
Předmět: | |
Zdroj: | FOCUS. 10:492-505 |
ISSN: | 1541-4108 1541-4094 |
Popis: | Objective:Two antidepressant medication combinations were compared with selective serotonin reuptake inhibitor monotherapy to determine whether either combination produced a higher remission rate in first-step acute-phase (12 weeks) and long-term (7 months) treatment. Method:The single-blind, prospective, randomized trial enrolled 665 outpatients at six primary and nine psychiatric care sites. Participants had at least moderately severe nonpsychotic chronic and/or recurrent major depressive disorder. Escitalopram (up to 20 mg/day) plus placebo, sustained-release bupropion (up to 400 mg/day) plus escitalopram (up to 20 mg/day), or extended-release venlafaxine (up to 300 mg/day) plus mirtazapine (up to 45 mg/day) was delivered (1:1:1 ratio) by using measurement-based care. The primary outcome was remission, defined as ratings of less than 8 and less than 6 on the last two consecutive applications of the 16-item Quick Inventory of Depressive Symptomatology—Self-Report. Secondary outcomes included side effect... |
Databáze: | OpenAIRE |
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