Histone Deacetylases and their Inhibitors in Colorectal Cancer Therapy: Current Evidence and Future Considerations
| Autor: | Nikolaos Garmpis, Konstantinos Kontzoglou, Christos Vallilas, Evangelos Koustas, Panagiotis Sarantis, Christos Damaskos, Nikolaos Trakas, Vasiliki E Georgakopoulou, Dimitrios Schizas, Athanasios Syllaios, Dimitrios Dimitroulis, Anna Garmpi, Alexandros Patsouras, Afroditi Nonni, Efstathios Antoniou |
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| Rok vydání: | 2022 |
| Předmět: |
Colorectal cancer
medicine.medical_treatment Antineoplastic Agents Biochemistry Histone Deacetylases Targeted therapy Pathogenesis Drug Discovery Gene expression medicine Humans Epigenetics Pharmacology Gastrointestinal tract Heterogeneous group biology business.industry Organic Chemistry medicine.disease digestive system diseases Histone Deacetylase Inhibitors Histone biology.protein Cancer research Molecular Medicine Colorectal Neoplasms business |
| Zdroj: | Current Medicinal Chemistry. 29:2979-2994 |
| ISSN: | 0929-8673 |
| DOI: | 10.2174/0929867328666210915105929 |
| Popis: | Abstract: Colorectal cancer (CRC) comprises a heterogeneous group of gastrointestinal tract tumors. It is a multifactorial disease, and a plethora of distinct factors are involved in its pathogenesis and pathophysiology. The development of CRC is not limited to genetic changes, but epigenetic and environmental factors are also involved. Among the epigenetic factors, histone deacetylases (HDACs), a group of epigenetic enzymes that regulate gene expression, have been reported to be over-expressed in CRC. HDACs and their inhibitors seem to play an important role in the molecular pathophysiology of CRC. The aim of this review was to define the role of HDAC inhibitors as potential anticancer agents against CRC. |
| Databáze: | OpenAIRE |
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