Association of polymorphisms in glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) with idiopathic azoospermia or oligospermia in Sichuan, China
| Autor: | Shao-hong Zhang, Da-Ke Xiong, Jianhui Zhang, Xianping Ding, Hong-Han Chen |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Infertility China medicine.medical_specialty Genotype Urology Molecular Sequence Data lcsh:RC870-923 genetic polymorphism glutathione S-transferase idiopathic infertility male factor Male infertility GSTP1 Asian People Risk Factors Internal medicine medicine Humans Genetic Predisposition to Disease Infertility Male Azoospermia Glutathione Transferase Genetics Polymorphism Genetic Base Sequence business.industry Case-control study Oligospermia General Medicine Odds ratio lcsh:Diseases of the genitourinary system. Urology medicine.disease Endocrinology Glutathione S-Transferase pi Case-Control Studies Original Article business |
| Zdroj: | Asian Journal of Andrology Asian Journal of Andrology, Vol 17, Iss 3, Pp 481-486 (2015) |
| ISSN: | 1008-682X |
| DOI: | 10.4103/1008-682x.143737 |
| Popis: | The reported effects of the glutathione S-transferase (GSTs) genes (GSTM1, GSTT1, and GSTP1) on male factor infertility have been inconsistent and even contradictory. Here, we conducted a case-control study to investigate the association between functionally important polymorphisms in GST genes and idiopathic male infertility. The study group consisted of 361 men with idiopathic azoospermia, 118 men with idiopathic oligospermia, and 234 age-matched healthy fertile male controls. Genomic DNA was extracted from the peripheral blood, and analyzed by polymerase chain reaction and restriction fragment length polymorphism analysis. There was a significant association between the GSTP1 variant genotype (Ile/Val + Val/Val) with idiopathic infertility risk (odds ratio [OR]: 1.53; 95% confidence interval [CI]: 1.11-2.11; P = 0.009). Similarly, a higher risk of infertility was noted in individuals carrying a genotype combination of GSTT1-null and GSTP1 (Ile/Val + Val/Val) (OR: 2.17; 95% CI: 1.43-3.31; P = 0.0002). These results suggest an increased risk of the GSTP1 variant genotype (Ile/Val + Val/Val) for developing male factor infertility. Our findings also underrate the significance of the effect of GSTM1 and/or GSTT1 (especially the former) in modulating the risk of male infertility in males from Sichuan, southwest China. |
| Databáze: | OpenAIRE |
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